P7C3-A20

• CAT Number: I008535
• CAS Number: 1235481-90-9
• Molecular Formula: C22H19Br2FN2O
• Molecular Weight: 506.21
• Purity: ≥95%
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• Related CAS: 1485572-67-5(hydrochloride)
• InChI: InChI=1S/C22H19Br2FN2O/c1-28-18-4-2-3-17(11-18)26-12-16(25)13-27-21-7-5-14(23)9-19(21)20-10-15(24)6-8-22(20)27/h2-11,16,26H,12-13H2,1H3
• InChIKey: XNLTWMQBJFWQOU-UHFFFAOYSA-N
• SMILES: COC1=CC(NCC(F)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3)=CC=C1

P7C3-A20 (CAT: I008535) is a member of the P7C3 family of neuroprotective compounds. It acts as a potent and selective antagonist of the apoptotic cell death pathway and exhibits neuroprotective effects. P7C3-A20 has been shown to promote the survival and growth of newborn neurons in the hippocampus, a brain region involved in learning and memory. It has also demonstrated efficacy in various models of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). Additionally, P7C3-A20 has shown potential in enhancing cognitive function and improving behavioral outcomes.

Reference

1: Loris ZB, Pieper AA, Dietrich WD. Corrigendum to /The neuroprotective compound
P7C3-A20 promotes neurogenesis and improves cognitive function after stroke/
[Exp. Neurol. 290 (2017) 63-73]. Exp Neurol. 2017 Dec;298(Pt A):134. doi:
10.1016/j.expneurol.2017.04.016. Epub 2017 May 13. PubMed PMID: 28511786.
2: Loris ZB, Hynton JR, Pieper AA, Dietrich WD. Beneficial Effects of Delayed
P7C3-A20 Treatment After Transient MCAO in Rats. Transl Stroke Res. 2017 Aug 25.
doi: 10.1007/s12975-017-0565-z. [Epub ahead of print] PubMed PMID: 28842830.
3: Loris ZB, Pieper AA, Dietrich WD. The neuroprotective compound P7C3-A20
promotes neurogenesis and improves cognitive function after ischemic stroke. Exp
Neurol. 2017 Apr;290:63-73. doi: 10.1016/j.expneurol.2017.01.006. Epub 2017 Jan
8. PubMed PMID: 28077334.
4: Wang SN, Xu TY, Wang X, Guan YF, Zhang SL, Wang P, Miao CY. Neuroprotective
Efficacy of an Aminopropyl Carbazole Derivative P7C3-A20 in Ischemic Stroke. CNS
Neurosci Ther. 2016 Sep;22(9):782-8. doi: 10.1111/cns.12576. Epub 2016 Jun 23.
PubMed PMID: 27333812.