p38-(alpha) MAPK-IN-1

• CAT Number: I013147
• CAS Number: 443913-15-3
• Molecular Formula: C₂₇H₃₅N₅O₃
• Molecular Weight: 477.6
• Purity: ≥95%
• Target: p38 MAPK
• Solubility: DMSO
• Storage: Store at -20°C
• IUPAC Name: 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)phenyl]urea
• InChI: InChI=1S/C27H35N5O3/c1-20-5-9-22(10-6-20)32-25(19-24(30-32)27(2,3)4)29-26(33)28-21-7-11-23(12-8-21)35-18-15-31-13-16-34-17-14-31/h5-12,19H,13-18H2,1-4H3,(H2,28,29,33)
• InChIKey: FRZNJFWQVYAVCE-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C=C3)OCCN4CCOCC4

p38-α MAPK-IN-1（Cat No.:I013147） is a compound that acts as an inhibitor of MAPK14, specifically targeting p38-α. It displays an IC50 value of 2300 nM in an EFC (Enzyme Fragment Complementation) displacement assay and 5500 nM in an HTRF (Homogeneous Time-Resolved Fluorescence) assay. By inhibiting the activity of p38-α, p38-α MAPK-IN-1 may modulate cellular signaling pathways associated with p38-α MAPK, which is involved in various biological processes and diseases.

Reference

[1]. Kluter S, et al. Displacement assay for the detection of stabilizers of inactive kinase conformations. J Med Chem. 2010 Jan 14;53(1):357-67.