oxypertine

• CAT Number: M070453
• CAS Number: 153-87-7
• Molecular Formula: C23H29N3O2
• Molecular Weight: 379.504
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: 5,6-dimethoxy-2-methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-indole
• InChI: InChI=1S/C23H29N3O2/c1-17-19(20-15-22(27-2)23(28-3)16-21(20)24-17)9-10-25-11-13-26(14-12-25)18-7-5-4-6-8-18/h4-8,15-16,24H,9-14H2,1-3H3
• InChIKey: XCWPUUGSGHNIDZ-UHFFFAOYSA-N
• SMILES: CC1=C(C2=CC(=C(C=C2N1)OC)OC)CCN3CCN(CC3)C4=CC=CC=C4

Oxypertine, also known as Win-18501 and Forit, is an indole-derivative antipsychotic with general properties similar to those of the phenothiazine and chlorpromazine. Oxypertine is used as a treatment for various psychoses including schizophrenia, mania, disturbed behaviour, and severe anxiety.

Reference

1:[Effects of mianserin hydrochloride on delirium: comparison with the effects of oxypertine and haloperidol]. Nakamura J, Uchimura N, Yamada S, Nakazawa Y.Nihon Shinkei Seishin Yakurigaku Zasshi. 1994 Aug;14(4):269-77. Japanese. PMID: 7975931 2:Effects of sulpiride and oxypertine on the dopaminergic system in the rat striatum. Motohashi N, Takashima M, Mataga N, Nishikawa T, Ogawa A, Watanabe S, Toru M.Neuropsychobiology. 1992;25(1):29-33. PMID: 1351265 3:Oxypertine in tardive dyskinesia: a long-term controlled study. Soni SD, Freeman HL, Bamrah JS, Sampath G.Acta Psychiatr Scand. 1986 Nov;74(5):446-50. PMID: 2880458 4:Neurochemical and behavioral studies on the mode of action of oxypertine. Moroji T, Okuyama T, Hagino Y, Sekiguchi R.Arzneimittelforschung. 1986 May;36(5):804-8. PMID: 2873819 5:Oxypertine in tardive dyskinesia. Youssef HA.Ir Med J. 1985 Nov;78(11):340. No abstract available. PMID: 2867066 6:Oxypertine in tardive dyskinesia. O/’Shea B, Falvey J.Ir Med J. 1985 Jul;78(7):202-3. No abstract available. PMID: 2863234 7:Urinary excretion of catecholamines and their metabolites in chronic schizophrenics treated with oxypertine and chlorpromazine. Kiriike N, Uete T, Motomura K, Enomoto M, Murata K.Biol Psychiatry. 1984 Mar;19(3):417-22. No abstract available. PMID: 6144330 8:Oxypertine in tardive dyskinesia: an 8-week controlled study. Soni SD, Freeman HL, Hussein EM.Br J Psychiatry. 1984 Jan;144:48-52. PMID: 6140973 9:Tardive dyskinesia and neurotransmitters: effects of sodium valproate, cyproheptadine, oxypertine, hydroxyzine pamoate and Ca-hopantenate on monoamine metabolites, cyclic nucleotides and gamma-aminobutyric acid in human cerebrospinal fluid. Ogawa T, Nagao T, Kashiwabara K, Fujiwara Y, Harada T, Otsuki S.Clin Ther. 1984;7 Spec No:1-17. PMID: 6085032 10:Determination of oxypertine in human serum by high-performance liquid chromatography. Minatogawa Y, Igarashi Y, Noguchi T.J Chromatogr. 1983 May 13;274:413-6. No abstract available. PMID: 6135702