Oxcarbazepine

  • CAT Number: A000627
  • CAS Number: 28721-07-5
  • Molecular Formula: C15H12N2O2
  • Molecular Weight: 252.3
  • Purity: ≥95%
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Oxcarbazepine is an anticonvulsant drug primarily used in the treatment of epilepsy. There is some evidence for oxcarbazepine as a mood-stabilizing agent and thus, it can be used as add-on therapy for bipolar disorder in patients that have failed or are unable to tolerate approved treatments.

Catalog Number A000627
CAS Number 28721-07-5
Molecular Formula

C15H12N2O2

Purity 95%
Target Sodium Channel
Solubility >9.1mg/mL in DMSO
Storage -20°C
InChI 1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19)
InChIKey CTRLABGOLIVAIY-UHFFFAOYSA-N
SMILES C1C2=CC=CC=C2N(C3=CC=CC=C3C1=O)C(=O)N
Reference

1: Maiti R, Mishra BR, Sanyal S, Mohapatra D, Parida S, Mishra A. Effect of
carbamazepine and oxcarbazepine on serum neuron-specific enolase in focal
seizures: A randomized controlled trial. Epilepsy Res. 2017 Oct 6;138:5-10. doi:
10.1016/j.eplepsyres.2017.10.003. [Epub ahead of print] PubMed PMID: 29028517.

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2: Erisgin Z, Ayas B, Nyengaard JR, Ercument Beyhun N, Terzi Y. The neurotoxic
effects of prenatal gabapentin and oxcarbazepine exposure on newborn rats. J
Matern Fetal Neonatal Med. 2017 Oct 5:1-11. doi: 10.1080/14767058.2017.1383378.
[Epub ahead of print] PubMed PMID: 28931341.
<br>

3: Shen C, Zhang B, Liu Z, Tang Y, Zhang Y, Wang S, Guo Y, Ding Y, Wang S, Ding
M. Effects of ABCB1, ABCC2, UGT2B7 and HNF4α genetic polymorphisms on
oxcarbazepine concentrations and therapeutic efficacy in patients with epilepsy.
Seizure. 2017 Oct;51:102-106. doi: 10.1016/j.seizure.2017.07.015. Epub 2017 Aug
1. PubMed PMID: 28837897.

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4: Erisgin Z, Tekelioglu Y. Flow cytometric examination of apoptotic effect on
brain tissue in postnatal period created by intrauterine oxcarbazepine and
gabapentin exposure. Bratisl Lek Listy. 2017;118(2):107-111. doi:
10.4149/BLL_2017_022. PubMed PMID: 28814092.
<br>

5: Rodrigues C, Chiron C, Rey E, Dulac O, Comets E, Pons G, Jullien V. Population
pharmacokinetics of oxcarbazepine and its monohydroxy derivative in epileptic
children. Br J Clin Pharmacol. 2017 Aug 3. doi: 10.1111/bcp.13392. [Epub ahead of
print] PubMed PMID: 28771787.

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6: Wang Y, Chen YB, Zhang YQ, Luo R, Wang H, Lv JL, Wang D, Zhu SQ, Lin ZD, Qin
J. Oxcarbazepine oral suspension in pediatric patients with partial seizures
and/or generalized tonic-clonic seizures: a multi-center, single arm,
observational study in China. World J Pediatr. 2017 Dec;13(6):551-559. doi:
10.1007/s12519-017-0045-2. Epub 2017 Jun 22. PubMed PMID: 28646433.

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7: Ferreira A, Rodrigues M, Marques A, Falc&#227;o A, Alves G. Influence of the dual
combination of silymarin and (-)-epigallocatechin gallate, natural dietary
flavonoids, on the pharmacokinetics of oxcarbazepine in rats. Food Chem Toxicol.
2017 Aug;106(Pt A):446-454. doi: 10.1016/j.fct.2017.06.015. Epub 2017 Jun 8.
PubMed PMID: 28602600.
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8: Beken B, Can C, &#214;rencik A, Can N, Yaz&#305;c&#305;o&#287;lu M. Oxcarbazepine-induced
Stevens-Johnson syndrome: a pediatric case report. Oxf Med Case Reports. 2017 Jun
1;2017(6):omx028. doi: 10.1093/omcr/omx028. eCollection 2017 Jun. PubMed PMID:
28580160; PubMed Central PMCID: PMC5451893.
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9: Chen CY, Li X, Ma LY, Wu PH, Zhou Y, Feng Q, Cui YM. In Utero Oxcarbazepine
Exposure and Neonatal Abstinence Syndrome: Case Report and Brief Review of the
Literature. Pharmacotherapy. 2017 Jul;37(7):e71-e75. doi: 10.1002/phar.1955. Epub
2017 Jul 2. PubMed PMID: 28543284; PubMed Central PMCID: PMC5575550.
<br>

10: Berghuis B, van der Palen J, de Haan GJ, Lindhout D, Koeleman BPC, Sander JW;
EpiPGX Consortium. Carbamazepine- and oxcarbazepine-induced hyponatremia in
people with epilepsy. Epilepsia. 2017 Jul;58(7):1227-1233. doi:
10.1111/epi.13777. Epub 2017 May 24. PubMed PMID: 28542738.

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