Oxantel pamoate

• CAT Number: I004587
• CAS Number: 68813-55-8
• Molecular Formula: C13H16N2O C23H16O6
• Molecular Weight: 604.65
• Purity: ≥95%
• Target: Antiparasitic
• Solubility: 10 mM in DMSO
• Storage: Store at -20C

Oxantel pamoate is a widely available dewormer, potently against Trichuris muris and Hookworms.Target: AntiparasiticThe activity of the veterinary drug Oxantel pamoate is studied against Trichuris muris, Ancylostoma ceylanicum and Necator americanus. An ED50 of 4.7 mg/kg is calculated for Oxantel pamoate against T. muris in mice. Combinations of Oxantel pamoate with pyrantel pamoate behaved antagonistically (combination index (CI)=2.53). Oxantel pamoate combined with levamisole, albendazole or ivermectin using ratios based on their ED50s reveals antagonistic effects (CI=1.27, 1.90 and 1.27, respectively). A highly synergistic effect (CI=0.15) is observed when Oxantel pamoate-mebendazole is administered to T. muris-infected mice. Oxantel pamoate (10 mg/kg) lacks activity against Ancylostoma ceylanicum and Necator americanus [1].

Reference

1:Exposure of Heligmosomoides polygyrus and Trichuris muris to albendazole, albendazole sulfoxide, mebendazole and oxantel pamoate in vitro and in vivo to elucidate the pathway of drug entry into these gastrointestinal nematodes. Cowan N, Meier C, Neodo A, Keiser J.Int J Parasitol Drugs Drug Resist. 2017 Mar 24;7(2):159-173. doi: 10.1016/j.ijpddr.2017.03.005. [Epub ahead of print] PMID: 28371660 Free PMC Article2:In Vitro and In Vivo Drug Interaction Study of Two Lead Combinations, Oxantel Pamoate plus Albendazole and Albendazole plus Mebendazole, for the Treatment of Soil-Transmitted Helminthiasis. Cowan N, Vargas M, Keiser J.Antimicrob Agents Chemother. 2016 Sep 23;60(10):6127-33. doi: 10.1128/AAC.01217-16. Print 2016 Oct. PMID: 27480864 Free PMC Article3:Efficacy and reinfection with soil-transmitted helminths 18-weeks post-treatment with albendazole-ivermectin, albendazole-mebendazole, albendazole-oxantel pamoate and mebendazole. Speich B, Moser W, Ali SM, Ame SM, Albonico M, Hattendorf J, Keiser J.Parasit Vectors. 2016 Mar 2;9:123. doi: 10.1186/s13071-016-1406-8. PMID: 26935065 Free PMC Article4:Oxantel pamoate and deworming programmes. Maheu-Giroux M.Lancet Infect Dis. 2016 Jan;16(1):5-6. doi: 10.1016/S1473-3099(15)00305-9. Epub 2015 Sep 18. No abstract available. PMID: 26388170 5:Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study. Moser W, Ali SM, Ame SM, Speich B, Puchkov M, Huwyler J, Albonico M, Hattendorf J, Keiser J.Lancet Infect Dis. 2016 Jan;16(1):53-60. doi: 10.1016/S1473-3099(15)00271-6. Epub 2015 Sep 18. PMID: 26388169 6:Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infections: a four-arm, randomised controlled trial. Speich B, Ali SM, Ame SM, Bogoch II, Alles R, Huwyler J, Albonico M, Hattendorf J, Utzinger J, Keiser J.Lancet Infect Dis. 2015 Mar;15(3):277-84. doi: 10.1016/S1473-3099(14)71050-3. Epub 2015 Jan 12. PMID: 25589326 7:Oxantel pamoate-albendazole for Trichuris trichiura infection. McCarthy JS.N Engl J Med. 2014 May 15;370(20):1952-3. doi: 10.1056/NEJMc1403068#SA2. No abstract available. PMID: 24827044 8:Oxantel pamoate-albendazole for Trichuris trichiura infection. Yasukawa K.N Engl J Med. 2014 May 15;370(20):1952. doi: 10.1056/NEJMc1403068#SA1. No abstract available. PMID: 24827043 9:Oxantel pamoate-albendazole for Trichuris trichiura infection. Keiser J, Speich B, Utzinger J.N Engl J Med. 2014 May 15;370(20):1953-4. doi: 10.1056/NEJMc1403068. No abstract available. PMID: 24827042 Free Article10:Oxantel pamoate-albendazole for Trichuris trichiura infection. Speich B, Ame SM, Ali SM, Alles R, Huwyler J, Hattendorf J, Utzinger J, Albonico M, Keiser J.N Engl J Med. 2014 Feb 13;370(7):610-20. doi: 10.1056/NEJMoa1301956. PMID: 24521107 Free Article