OT-82

• CAT Number: I015470
• CAS Number: 1800487-55-1
• Molecular Formula: C₂₆H₂₁FN₄O
• Molecular Weight: 424.47
• Purity: ≥95%

OT-82 (CAT: I015470) is a potent, selective, and orally active inhibitor of NAMPT (nicotinamide phosphoribosyltransferase). It exhibits selective toxicity towards cells of hematopoietic origin and induces cell death in an NAD+ (nicotinamide adenine dinucleotide) dependent manner. OT-82 shows promise as an antineoplastic agent for the investigation of hematological malignancies. Its inhibitory activity against NAMPT suggests a potential role in disrupting NAD+ metabolism, a vital pathway for cellular energy regulation and DNA repair. Further research is underway to explore its therapeutic applications in hematological malignancies.

Reference

[1]. Korotchkina L, et al. OT-82, a novel anticancer drug candidate that targets the strong dependence of hematological malignancies on NAD biosynthesis.Leukemia. 2020 Jan 2.