OSS_128167 (Cat No.:I012947) is a specific SIRT6 inhibitor with IC50 of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 plays an antiviral role in HBV transcription and replication. OSS-128167 was also able to increase H3K9 acetylation and GLUT-1 expression levels.
| Catalog Number | I012947 |
| CAS Number | 887686-02-4 |
| Molecular Formula | C₁₉H₁₄N₂O₆ |
| Purity | 95% |
| Target | Sirtuin |
| Solubility | DMSO: 103.3 mg/mL |
| Storage | 2-8°C |
| IUPAC Name | 5-[[3-(furan-2-carbonylamino)benzoyl]amino]-2-hydroxybenzoic acid |
| InChI | InChI=1S/C19H14N2O6/c22-15-7-6-13(10-14(15)19(25)26)20-17(23)11-3-1-4-12(9-11)21-18(24)16-5-2-8-27-16/h1-10,22H,(H,20,23)(H,21,24)(H,25,26) |
| InChIKey | HTJWLEGCECXGSQ-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC(=C1)NC(=O)C2=CC=CO2)C(=O)NC3=CC(=C(C=C3)O)C(=O)O |
| Reference | [1]. Parenti MD, et al. Discovery of novel and selective SIRT6 inhibitors. J Med Chem. 2014 Jun 12;57(11):4796-804.<br>[2]. Cea M, et al. Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells. Blood. 2016 Mar 3;127(9):1138-50. |
