• CAT Number: I012947
  • CAS Number: 887686-02-4
  • Molecular Formula: C₁₉H₁₄N₂O₆
  • Molecular Weight: 366.32
  • Purity: ≥95%
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OSS_128167 (Cat No.:I012947) is a specific SIRT6 inhibitor with IC50 of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 plays an antiviral role in HBV transcription and replication. OSS-128167 was also able to increase H3K9 acetylation and GLUT-1 expression levels.

Catalog Number I012947
CAS Number 887686-02-4
Molecular Formula


Purity 95%
Target Sirtuin
Solubility DMSO: 103.3 mg/mL
Storage 2-8°C
IUPAC Name 5-[[3-(furan-2-carbonylamino)benzoyl]amino]-2-hydroxybenzoic acid
InChI InChI=1S/C19H14N2O6/c22-15-7-6-13(10-14(15)19(25)26)20-17(23)11-3-1-4-12(9-11)21-18(24)16-5-2-8-27-16/h1-10,22H,(H,20,23)(H,21,24)(H,25,26)

[1]. Parenti MD, et al. Discovery of novel and selective SIRT6 inhibitors. J Med Chem. 2014 Jun 12;57(11):4796-804.<br>[2]. Cea M, et al. Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells. Blood. 2016 Mar 3;127(9):1138-50.

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