OSS_128167

• CAT Number: I012947
• CAS Number: 887686-02-4
• Molecular Formula: C₁₉H₁₄N₂O₆
• Molecular Weight: 366.32
• Purity: ≥95%
• Target: Sirtuin
• Solubility: DMSO: 103.3 mg/mL
• Storage: 2-8°C
• IUPAC Name: 5-[[3-(furan-2-carbonylamino)benzoyl]amino]-2-hydroxybenzoic acid
• InChI: InChI=1S/C19H14N2O6/c22-15-7-6-13(10-14(15)19(25)26)20-17(23)11-3-1-4-12(9-11)21-18(24)16-5-2-8-27-16/h1-10,22H,(H,20,23)(H,21,24)(H,25,26)
• InChIKey: HTJWLEGCECXGSQ-UHFFFAOYSA-N
• SMILES: C1=CC(=CC(=C1)NC(=O)C2=CC=CO2)C(=O)NC3=CC(=C(C=C3)O)C(=O)O

OSS_128167 (Cat No.:I012947) is a specific SIRT6 inhibitor with IC50 of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 plays an antiviral role in HBV transcription and replication. OSS-128167 was also able to increase H3K9 acetylation and GLUT-1 expression levels.

Reference

[1]. Parenti MD, et al. Discovery of novel and selective SIRT6 inhibitors. J Med Chem. 2014 Jun 12;57(11):4796-804.[2]. Cea M, et al. Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells. Blood. 2016 Mar 3;127(9):1138-50.