Osimertinib-13CD3

• CAT Number: C000729
• CAS Number: 2254100-49-5
• Molecular Formula: C₂₇¹³CH₃₀D₃N₇O₂
• Molecular Weight: 503.62
• Purity: ≥95%
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Storage: -20°C, Hygroscopic

Osimertinib 13CD3 (Cat No.:C000729) is a deuterium-labeled derivative of osimertinib, a targeted therapy medication used in the treatment of non-small cell lung cancer (NSCLC) harboring specific epidermal growth factor receptor (EGFR) mutations. The deuterium substitution enhances molecular stability and aids in precise isotopic labeling for research purposes. Osimertinib-^13CD3 likely serves as an internal standard for quantification in pharmacokinetic and metabolic studies. By incorporating deuterium, researchers can accurately trace the compound’s fate in the body, providing insights into its absorption, distribution, metabolism, and excretion, ultimately advancing the understanding and optimization of osimertinib therapy.

Reference

Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);