Oseltamivir Phosphate

• CAT Number: A000321
• CAS Number: 204255-11-8
• Molecular Formula: C16H28N2O4 • H3PO4
• Molecular Weight: 410.4
• Purity: ≥95%
• Solubility: Limited solubility
• Storage: 3 years -20C powder
• IUPAC Name: ethyl (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate;phosphoric acid
• InChI: InChI=1S/C16H28N2O4.H3O4P/c1-5-12(6-2)22-14-9-11(16(20)21-7-3)8-13(17)15(14)18-10(4)19;1-5(2,3)4/h9,12-15H,5-8,17H2,1-4H3,(H,18,19);(H3,1,2,3,4)/t13-,14+,15+;/m0./s1
• InChIKey: PGZUMBJQJWIWGJ-ONAKXNSWSA-N
• SMILES: CCC(CC)OC1C=C(CC(C1NC(=O)C)N)C(=O)OCC.OP(=O)(O)O

Oseltamivir Phosphate (CAS 204255-11-8) is a potent and selective inhibitor of the neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza.
Oseltamivir Phosphate, anti-Neu1 antibodies, and matrix metalloproteinase-9-specific inhibitor block Neu1 activity associated with EGF-stimulated TNBC MDA-MB-231 cells
Oseltamivir Phosphate monotherapy may be the effective treatment therapy for TNBC(Triple-negative breast cancers).

Overview of Clinical Research

Oseltamivir is a Neuraminidase inhibitor. It is marketed in Influenza virus infections.

Reference

1.Huang, Hua, et al. "Transplacental transfer of oseltamivir phosphate and its metabolite oseltamivir carboxylate using the ex vivo human placenta perfusion model in Chinese Hans population." The Journal of Maternal-Fetal & Neonatal Medicine 30.11 (2017): 1288-1292.
2.de Oliveira, Joana T., et al. "Anti-influenza neuraminidase inhibitor oseltamivir phosphate induces canine mammary cancer cell aggressiveness." PloS one 10.4 (2015): e0121590.
3.Li, Ping, et al. "A simple and robust approach for evaluation of antivirals using a recombinant influenza virus expressing Gaussia luciferase." Viruses 10.6 (2018): 325.