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Org 27569

Org 27569

  • CAT Number: I005224
  • CAS Number: 868273-06-7
  • Molecular Formula: C24H28ClN3O
  • Molecular Weight: 409.95
  • Purity: ≥95%
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<p style=/line-height:25px/>Org 27569 is an allosteric modulator of cannabinoid CB1 receptor, induces a CB1 receptor state that is characterized by enhanced agonist affinity and decreased inverse agonist affinity.<br>IC50 value:<br>Target: CB1 receptor<br>Org 27569 is a potent CB1 receptor allosteric modulator (pEC50 = 8.24). Org 27569 significantly increases binding of the CB1 agonist [3H]CP 55.940 (pKb = 5.67) and decreases binding of the CB1 inverse agonist [3H]SR 141716A (pKb = 5.95). Org 27569 inhibits CB1 receptor antagonist efficacy in vitro (pKb = 7.57).</p>

Catalog Number I005224
CAS Number 868273-06-7
Molecular Formula

C24H28ClN3O

Purity 95%
Target Cannabinoid Receptor
Solubility DMSO: ≥ 52.2 mg/mL
Storage 3 years -20C powder
Reference

</br>1:Effects of the cannabinoid CB₁ receptor allosteric modulator ORG 27569 on reinstatement of cocaine- and methamphetamine-seeking behavior in rats. Jing L, Qiu Y, Zhang Y, Li JX.Drug Alcohol Depend. 2014 Oct 1;143:251-6. doi: 10.1016/j.drugalcdep.2014.08.004. Epub 2014 Aug 17. PMID: 25169627 Free PMC Article</br>2:In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569. Gamage TF, Ignatowska-Jankowska BM, Wiley JL, Abdelrahman M, Trembleau L, Greig IR, Thakur GA, Tichkule R, Poklis J, Ross RA, Pertwee RG, Lichtman AH.Behav Pharmacol. 2014 Apr;25(2):182-5. doi: 10.1097/FBP.0000000000000027. PMID: 24603340 Free PMC Article</br>3:A key agonist-induced conformational change in the cannabinoid receptor CB1 is blocked by the allosteric ligand Org 27569. Fay JF, Farrens DL.J Biol Chem. 2012 Sep 28;287(40):33873-82. Epub 2012 Jul 30. PMID: 22846992 Free PMC Article

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