For research use only. Not for therapeutic Use.
ONC206(CAT:I017529) is a next-generation analogue of the TRAIL inducer ONC201 and a selective nanomolar antagonist of D2-like dopamine receptors (DRD2/3/4), with minimal activity at D1-like receptors. It shows broad antitumor activity, significantly suppressing tumor cell migration and invasion in vitro, including ONC201- and TRAIL-resistant HCT116 Bax−/− cells at 0.05 μM (48 h) without cytotoxicity or antiproliferative effects. Mechanistically, ONC206 engages the integrated stress response (ISR) and TRAIL pathway to drive tumor growth arrest and cell death. In a mouse model, oral ONC206 (100 mg/kg, every 10 days) produces significant tumor growth inhibition.
| CAS Number | 1638178-87-6 |
| Synonyms | 11-benzyl-7-[(2,4-difluorophenyl)methyl]-2,5,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-one |
| Molecular Formula | C23H22F2N4O |
| Purity | ≥95% |
| IUPAC Name | 11-benzyl-7-[(2,4-difluorophenyl)methyl]-2,5,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-one |
| InChI | InChI=1S/C23H22F2N4O/c24-18-7-6-17(20(25)12-18)14-29-22(30)19-15-27(13-16-4-2-1-3-5-16)10-8-21(19)28-11-9-26-23(28)29/h1-7,12H,8-11,13-15H2 |
| InChIKey | ITMGVSSHWMTJRR-UHFFFAOYSA-N |
| SMILES | C1CN(CC2=C1N3CCN=C3N(C2=O)CC4=C(C=C(C=C4)F)F)CC5=CC=CC=C5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
