Omeprazole

• CAT Number: A000620
• CAS Number: 73590-58-6
• Molecular Formula: C17H19N3O3S
• Molecular Weight: 345.4
• Purity: ≥95%
• Target: Autophagy
• Solubility: >17.3mg/mL in DMSO
• Storage: -20°C
• InChI: 1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
• InChIKey: SUBDBMMJDZJVOS-UHFFFAOYSA-N
• SMILES: CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC

Omeprazole (Cat.No:A000620) is a medication used in the treatment of gastroesophageal reflux disease, peptic ulcer disease, and Zollinger–Ellison syndrome. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. Omeprazole is a proton pump inhibitor and as such blocks the release of stomach acid.

Reference

1: Dohr J, Hunzelmann N, Brown A. [Immediate type reactions to proton pump
inhibitors using pantoprazole and omeprazole as examples]. Hautarzt. 2017 Oct 30.
doi: 10.1007/s00105-017-4075-4. [Epub ahead of print] German. PubMed PMID:
29085952.

2: Uchiyama T, Higurashi T, Kuriyama H, Kondo Y, Hata Y, Nakajima A. Oral
esomeprazole vs injectable omeprazole for the prevention of hemorrhage after
endoscopic submucosal dissection. World J Gastrointest Endosc. 2017 Oct
16;9(10):514-520. doi: 10.4253/wjge.v9.i10.514. PubMed PMID: 29085562; PubMed
Central PMCID: PMC5648994.

3: Patel VB, Patel AD, Shah DA. Stability Indicating Liquid Chromatographic
Method for Simultaneous determination of Aspirin and Omeprazole. Curr Drug Discov
Technol. 2017 Oct 23. doi: 10.2174/1570163814666171023144105. [Epub ahead of
print] PubMed PMID: 29065836.

4: Tangamornsuksan W, Thiansupornpong P, Morasuk T, Lohitnavy O, Lohitnavy M. A
pharmacokinetic model of drug-drug interaction between clopidogrel and omeprazole
at CYP2C19 in humans. Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:2704-2707.
doi: 10.1109/EMBC.2017.8037415. PubMed PMID: 29060457.

5: Yasumuro O, Uchida S, Kashiwagura Y, Suzuki A, Tanaka S, Inui N, Watanabe H,
Namiki N. Changes in gefitinib, erlotinib and osimertinib pharmacokinetics under
various gastric pH levels following oral administration of omeprazole and
vonoprazan in rats. Xenobiotica. 2017 Nov 17:1-7. doi:
10.1080/00498254.2017.1396379. [Epub ahead of print] PubMed PMID: 29057719.

6: Huang L, Qi DJ, He W, Xu AM. Omeprazole promotes carcinogenesis of
fore-stomach in mice with co-stimulation of nitrosamine. Oncotarget. 2017 Jul
31;8(41):70332-70344. doi: 10.18632/oncotarget.19696. eCollection 2017 Sep 19.
PubMed PMID: 29050283; PubMed Central PMCID: PMC5642558.

7: Collares-Pelizaro RVA, Santos JS, Nonino CB, Dos Reis Dias LA, Gaitani CM,
Salgado W Jr. Correction to: Omeprazole Absorption and Fasting Gastrinemia After
Roux-en-Y Gastric Bypass. Obes Surg. 2017 Oct 18. doi: 10.1007/s11695-017-2956-3.
[Epub ahead of print] PubMed PMID: 29047048.

8: Veltri KT. Yosprala®: A Fixed Dose Combination of Aspirin and Omeprazole.
Cardiol Rev. 2017 Oct 17. doi: 10.1097/CRD.0000000000000174. [Epub ahead of
print] PubMed PMID: 29045287.

9: Kusama T, Toda A, Shimizu M, Uehara S, Inoue T, Uno Y, Utoh M, Sasaki E,
Yamazaki H. Association with polymorphic marmoset cytochrome P450 2C19 of in vivo
hepatic clearances of chirally separated R-omeprazole and S-warfarin using
individual marmoset physiologically based pharmacokinetic models. Xenobiotica.
2017 Nov 10:1-6. doi: 10.1080/00498254.2017.1393121. [Epub ahead of print] PubMed
PMID: 29034770.

10: Denisenko NP, Sychev DA, Sizova ZM, Smirnov VV, Ryzhikova KA, Sozaeva ZA,
Grishina EA. Urine metabolic ratio of omeprazole in relation to CYP2C19
polymorphisms in Russian peptic ulcer patients. Pharmgenomics Pers Med. 2017 Sep
27;10:253-259. doi: 10.2147/PGPM.S141935. eCollection 2017. PubMed PMID:
29033601; PubMed Central PMCID: PMC5628683.