Lomitapide - CAS 182431-12-5

Lomitapide is a MTP inhibitor. Lomitapid is a novel agent for the treatment of homozygous familial hypercholesterolemia. Lomitapide is an orally active inhibitor of microsomal triglyceride transfer protein that is indicated as an adjunct to a low-fat diet and other lipid-lowering treatments, including LDL apheresis where available for the reduction of LDL-C, total cholesterol, apolipoprotein B, and non-high-density lipoprotein cholesterol in adult patients with HoFH.

Catalog Number: A000126

CAS Number: 182431-12-5

PubChem Substance ID:355038163

Molecular Formula: C₃₉H₃₇F₆N₃O₂

Molecular Weight:693.72

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms182431-12-5; Juxtapid; Lojuxta; BMS-201038; AEGR 733

Property

Molecular Formula: C₃₉H₃₇F₆N₃O₂
Molecular Weight693.72
Target:MTP inhibitor
Purity≥95%
Storage-20°C

Computed Descriptor

InChIInChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
InChIKeyMBBCVAKAJPKAKM-UHFFFAOYSA-N
SMILESC1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F