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OMEGA-CONOTOXIN MVIIC

OMEGA-CONOTOXIN MVIIC

  • CAT Number: M092363
  • CAS Number: 147794-23-8
  • Molecular Formula: C106H178N40O32S7
  • Molecular Weight: 2749.258
  • Purity: ≥95%
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<p>It is a blocker of <strong>omega-conotoxin GVIA</strong>-insensitive Ca2+ channels, including P-type Ca2+-channels in cerebellar Purkinge cells.</p><br />A 26-amino acid peptide with 3 disulfide bridges<!–C<SUB>106</SUB>H<SUB>178</SUB>N<SUB>40</SUB>O<SUB>32</SUB>S<SUB>7</SUB>–>, synthetic, originally from <I>Conus magus</I> molluscan venom</br><p><strong>Omega-CgTx-MVIIC</strong> inhibits presynaptic Ca2+ channels, including the Ca2+ channels responsible for Ca2+ uptake by rat brain synaptosomes, the P-type Ca2+ channels in cerebellar Purkinje cells, and a significant fraction of&nbsp;<strong>Omega-CgTx-MVIIC</strong>-resistant currents in hippocampal CA1 neurons.<br /><br /><strong>Omega-CgTx-MVIIC</strong>&nbsp;also presents an inhibition of&nbsp;<strong>Omega-CgTx-MVIIC</strong>-GVIA-resistant depolarization-induced neurotransmetter release in cerebellar neurons of rats</p></br>

Catalog Number M092363
CAS Number 147794-23-8
Synonyms

2-((1Z,3R,4E,6S,7E,9S,10E,12S,13E,15S,16E,18S,19E,21S,22E,24R,29R,30Z,32S,33Z,36Z,38S,39Z,41S,42Z,45Z,47R,50S,56S,59R,64R,65Z,67S,68Z,71Z,73S,74Z,77Z,79S,84aS,85E)-64-amino-9,32,67,73-tetrakis(4-aminobutyl)-6,38,41-tris(3-guanidinopropyl)-1,4,7,10,13

Molecular Formula

C106H178N40O32S7

Purity 95%
Target Calcium Channel
Solubility Soluble to 1 mg/ml in sterile water
Storage Desiccate at -20C
InChI InChI=1S/C106H178N40O32S7/c1-53-103(178)146-36-15-23-75(146)101(176)144-74-52-185-183-49-71-89(164)126-43-79(154)130-62(21-13-34-120-105(115)116)90(165)133-60(20-12-33-119-104(113)114)87(162)124-42-78(153)129-61(18-6-10-31-109)91(166)140-70(83(112)158)48-181-184-51-73(100(175)143-72(99(174)139-68(45-147)88(163)125-44-80(155)131-69(46-148)97(172)141-71)50-182-180-47-57(111)84(159)132-59(17-5-9-30-108)86(161)123-41-77(152)128-58(16-4-8-29-107)85(160)122-40-76(151)127-53)142-96(171)67(39-81(156)157)138-95(170)66(38-55-24-26-56(150)27-25-55)137-93(168)65(28-37-179-3)136-102(177)82(54(2)149)145-94(169)63(19-7-11-32-110)134-92(167)64(135-98(74)173)22-14-35-121-106(117)118/h24-27,53-54,57-75,82,147-150H,4-23,28-52,107-111H2,1-3H3,(H2,112,158)(H,122,160)(H,123,161)(H,124,162)(H,125,163)(H,126,164)(H,127,151)(H,128,152)(H,129,153)(H,130,154)(H,131,155)(H,132,159)(H,133,165)(H,134,167)(H,135,173)(H,136,177)(H,137,168)(H,138,170)(H,139,174)(H,140,166)(H,141,172)(H,142,171)(H,143,175)(H,144,176)(H,145,169)(H,156,157)(H4,113,114,119)(H4,115,116,120)(H4,117,118,121)/t53-,54+,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,82-/m0/s1
InChIKey FHVUTHWUIUXZBY-QLANQDRJSA-N
SMILES CC1C(=O)N2CCCC2C(=O)NC3CSSCC4C(=O)NCC(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(CSSCC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NCC(=O)N1)CCCCN)CCCCN)N)C(=O)NC(C(=O)NCC(=O)NC(C(=O)N4)CO)CO)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC3=O)CCCNC(=N)N)CCCCN)C(C)O)CCSC)CC5=CC=C(C=C5)O)CC(=O)O)C(=O)N)CCCCN)CCCNC(=N)N)CCCNC(=N)N
Reference

– Hillyard et al., /A new Conus peptide ligand for mammalian presynaptic Ca2<SUP>+</SUP> channels./ Neuron (1992). 9:69-77<br /><br /><br /><br />

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