Ombitasvir

• CAT Number: I001034
• CAS Number: 1258226-87-7
• Molecular Formula: C50H67N7O8
• Molecular Weight: 894.11
• Purity: ≥95%
• Target: HCV NS5A
• Solubility: DMSO: ≥ 33 mg/mL
• Storage: 3 years -20C powder
• IC50: 14 pM and 5 pM (EC50, for genotype 1a-H77 and 1b-Con1) [2]

Ombitasvir (ABT-267) is an inhibitor of HCV NS5A. ABT-267 inhibits replication of HCV subgenomic replicons in cell culture assays with EC50 values of 14 pM and 5 pM against genotype 1a-H77 and 1b-Con1, respectively.IC50 value: 14 pM and 5 pM (EC50, for genotype 1a-H77 and 1b-Con1) [2]Target: HCV NS5Ain vitro: Ombitasvir is a NS5A inhibitor. [1] The EC50 value of ABT-267 against stable cell line replicons containing NS5A from HCV genotypes 2a, 2b, 3a, 4a, 5a or 6a was 12.4, 4.3, 19.3, 1.7, 3.2 or 366 pM, respectively. The relatively similar EC50 values for all major HCV genotypes are noted. It is likely that ABT-267 might have been a valuable drug for the treatment of genotype 3; however, it will only be available co-formulated with a NS3/4A inhibitor with significantly reduced activity against this genotype. Also, the lower activity against genotype 6a is noted. The molecular background for this has not been clarified. ABT-267 had a TD50 of > 32,000,000 pM in an MTT cytotoxicity assay, producing a therapeutic index that exceeded 2 million-fold. [2]

Reference

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