Olsalazine Sodium

• CAT Number: A000552
• CAS Number: 6054-98-4
• Molecular Formula: C14H8N2O6.2Na
• Molecular Weight: 346.2
• Purity: ≥95%
• Target: Antibiotic
• Solubility: Soluble in DMSO > 10 mM
• Storage: 3 years -20C powder

Olsalazine Sodium is an anti-inflammatory prodrug, which consists of two 5-ASA moieties linked by an azo bond.Olsalazine displays multiple effects on intestinal electrolyte. In vitro application of Olsalazine (< 2.89 mM) increases the secretion of both sodium and chloride ions and decreases chloride ion absorption in rat and rabbit ileal mucosa. Concentration of Olsalazine < 11.5 mM also dose-dependently decreases net sodium and, to a greater degree, chloride absorption in the isolated rat colon. Potassium secretion is also increases but only at a high Olsalazine concentration (11.5 mM). Olsalazine also inhibits absorption of glucose and lactose in isolated rat jejunum.Olsalazine is developed as a way of delivering mesalazine to the colon, since very little of parent molecule is absorbed from the gastrointestinal tract following oral administration. In the colon, azoreductase bacteria cleave the azo bond, releasing 2 molecules of mesalazine which has demonstrated therapeutic effect in inflammatory bowel diseases.