Olaquindox

• CAT Number: R009474
• CAS Number: 23696-28-8
• Molecular Formula: C12H13N3O4
• Molecular Weight: 263.253
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: N-(2-hydroxyethyl)-3-methyl-4-oxido-1-oxoquinoxalin-1-ium-2-carboxamide
• InChI: InChI=1S/C12H13N3O4/c1-8-11(12(17)13-6-7-16)15(19)10-5-3-2-4-9(10)14(8)18/h2-5,16H,6-7H2,1H3,(H,13,17)
• InChIKey: TURHTASYUMWZCC-UHFFFAOYSA-N
• SMILES: CC1=C([N+](=O)C2=CC=CC=C2N1[O-])C(=O)NCCO

Olaquindox is used in prevention of swine dysentary. It is also a growth promoting additive in pig feed.

Reference

1:TCS2 Increases Olaquindox-Induced Apoptosis by Upregulation of ROS Production and Downregulation of Autophagy in HEK293 Cells. Li D, Zhao K, Yang X, Xiao X, Tang S.Molecules. 2017 Apr 7;22(4). pii: E595. doi: 10.3390/molecules22040595. PMID: 28387735 Free Article2:GADD45a Regulates Olaquindox-Induced DNA Damage and S-Phase Arrest in Human Hepatoma G2 Cells via JNK/p38 Pathways. Li D, Dai C, Yang X, Li B, Xiao X, Tang S.Molecules. 2017 Jan 13;22(1). pii: E124. doi: 10.3390/molecules22010124. PMID: 28098804 Free Article3:Molecularly imprinted electrochemical sensor based on Au nanoparticles in carboxylated multi-walled carbon nanotubes for sensitive determination of olaquindox in food and feedstuffs. Wang H, Yao S, Liu Y, Wei S, Su J, Hu G.Biosens Bioelectron. 2017 Jan 15;87:417-421. doi: 10.1016/j.bios.2016.08.092. Epub 2016 Aug 28. PMID: 27589405 4:Effect of GADD45a on olaquindox-induced apoptosis in human hepatoma G2 cells: Involvement of mitochondrial dysfunction. Li D, Dai C, Zhou Y, Yang X, Zhao K, Xiao X, Tang S.Environ Toxicol Pharmacol. 2016 Sep;46:140-6. doi: 10.1016/j.etap.2016.07.012. Epub 2016 Jul 19. PMID: 27458702 5:Dual-label quantum dot-based immunoassay for simultaneous determination of Carbadox and Olaquindox metabolites in animal tissues. Le T, Zhu L, Yu H.Food Chem. 2016 May 15;199:70-4. doi: 10.1016/j.foodchem.2015.11.116. Epub 2015 Nov 26. PMID: 26775945 6:Olaquindox induces DNA damage via the lysosomal and mitochondrial pathway involving ROS production and p53 activation in HEK293 cells. Yang Y, Jiang L, She Y, Chen M, Li Q, Yang G, Geng C, Tang L, Zhong L, Jiang L, Liu X.Environ Toxicol Pharmacol. 2015 Nov;40(3):792-9. doi: 10.1016/j.etap.2015.09.008. Epub 2015 Sep 16. PMID: 26453893 7:HPLC-MS/MS method validation for the detection of carbadox and olaquindox in poultry and swine feedingstuffs. Souza Dibai WL, de Alkimin Filho JF, da Silva Oliveira FA, Sampaio de Assis DC, Camargos Lara LJ, de Figueiredo TC, de Vasconcelos Cançado S.Talanta. 2015 Nov 1;144:740-4. doi: 10.1016/j.talanta.2015.07.029. Epub 2015 Jul 11. PMID: 26452885 Free Article8:In vivo studies to highlight possible illegal treatments of rabbits with carbadox and olaquindox. Segato G, Biancotto G, Agnoletti F, Berto G, Montesissa C, Benetti C.Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(12):1976-91. doi: 10.1080/19440049.2015.1086822. Epub 2015 Oct 21. PMID: 26400201 9:[Research on olaquindox induced endoplasmic reticulum stress related apoptosis on nephrotoxicity]. Li Z, Yu C, Chen X, Zhang B, Cao P, Li B, Xiao J.Wei Sheng Yan Jiu. 2015 May;44(3):444-50. Chinese. PMID: 26137627 10:Hepatoprotective effects of a Chinese herbal formulation, Yingchen decoction, on olaquindox-induced hepatopancreas injury in Jian carp (Cyprinus carpio var. Jian). Zhou J, Li C, Wang L, Ji H, Zhu T.Fish Physiol Biochem. 2015 Feb;41(1):153-63. doi: 10.1007/s10695-014-0013-x. Epub 2014 Dec 5. PMID: 25477196