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NucPE1

NucPE1

  • CAT Number: I013399
  • CAS Number: 1404091-23-1
  • Molecular Formula: C₂₉H₃₀BNO₅
  • Molecular Weight: 483.36
  • Purity: ≥95%
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NucPE1 (Nuclear Peroxy Emerald 1) is a nuclear-localized fluorescent hydrogen peroxide that is specifically localized to cellular nuclei without appended targeting moieties.

Catalog Number I013399
CAS Number 1404091-23-1
Molecular Formula

C₂₉H₃₀BNO₅

Purity 95%
Target Dye Reagents
Solubility DMSO
IUPAC Name 3//'-(ethylamino)-2//'-methyl-6//'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[2-benzofuran-3,9//'-xanthene]-1-one
InChI InChI=1S/C29H30BNO5/c1-7-31-23-16-25-22(14-17(23)2)29(20-11-9-8-10-19(20)26(32)34-29)21-13-12-18(15-24(21)33-25)30-35-27(3,4)28(5,6)36-30/h8-16,31H,7H2,1-6H3
InChIKey GHPDUBPWQBBRPG-UHFFFAOYSA-N
SMILES B1(OC(C(O1)(C)C)(C)C)C2=CC3=C(C=C2)C4(C5=CC=CC=C5C(=O)O4)C6=CC(=C(C=C6O3)NCC)C
Reference

[1]. Stanicka J, et al. NADPH oxidase-generated hydrogen peroxide induces DNA damage in mutant FLT3-expressing leukemia cells. J Biol Chem. 2015 Apr 10;290(15):9348-61. <br>[2]. Dickinson BC, et al. A nuclear-localized fluorescent hydrogen peroxide probe for monitoring sirtuin-mediated oxidative stress responses in vivo. Chem Biol. 2011 Aug 26;18(8):943-8.

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