Nucleoprotein (396-404)

• CAT Number: I020161
• CAS Number: 158475-79-7
• Molecular Formula: C₅₀H₇₁N₁₃O₁₄
• Molecular Weight: 1078.18
• Purity: ≥95%
• IUPAC Name: (2S,3S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-4-amino-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S)-5-amino-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-4-oxobutanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoic acid
• InChI: InChI=1S/C50H71N13O14/c1-3-27(2)42(50(76)77)62-47(73)34(24-29-13-8-5-9-14-29)60-45(71)31(16-19-37(52)64)57-41(68)26-56-44(70)35(25-40(55)67)61-46(72)32(17-20-38(53)65)58-48(74)36-15-10-22-63(36)49(75)33(18-21-39(54)66)59-43(69)30(51)23-28-11-6-4-7-12-28/h4-9,11-14,27,30-36,42H,3,10,15-26,51H2,1-2H3,(H2,52,64)(H2,53,65)(H2,54,66)(H2,55,67)(H,56,70)(H,57,68)(H,58,74)(H,59,69)(H,60,71)(H,61,72)(H,62,73)(H,76,77)/t27-,30-,31-,32-,33-,34-,35-,36-,42-/m0/s1
• InChIKey: LXMKAPMSYYEFSM-FQQQFTRISA-N
• SMILES: CCC(C)C(C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CCC(=O)N)NC(=O)CNC(=O)C(CC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C2CCCN2C(=O)C(CCC(=O)N)NC(=O)C(CC3=CC=CC=C3)N

Nucleoprotein (396-404)（Cat No.:I020161） is a specific fragment (amino acids 396 to 404) derived from the nucleoprotein of lymphocytic choriomeningitis virus (LCMV). This fragment represents an immunodominant epitope that is presented by the H-2D(b) major histocompatibility complex (MHC) molecule. It is commonly used as a molecular model for studying viral antigens and immune responses. Nucleoprotein (396-404) can be utilized in experiments to investigate T-cell recognition, immune activation, and vaccine development against LCMV and related viruses.

Reference

[1]. Gairin JE, et al. Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes. J Virol. 1995 Apr;69(4):2297-305.[2]. Hudrisier D, et al. Structural and functional identification of major histocompatibility complex class I-restricted self-peptides as naturally occurring molecular mimics of viral antigens. Possible role in CD8+ T cell-mediated, virus-induced autoimmune disease. J Biol Chem. 2001 Jun 1;276(22):19396-403. Epub 2001 Mar 8.