NSC319726

• CAT Number: I004668
• CAS Number: 71555-25-4
• Molecular Formula: C11H14N4S
• Molecular Weight: 234.32
• Purity: ≥95%
• Synonyms: N-[(Z)-1-pyridin-2-ylethylideneamino]azetidine-1-carbothioamide
• Target: p53
• Solubility: DMSO: ≤ 27.5 mg/mL
• Storage: Store at -20°C
• IC50: 8 nM
• IUPAC Name: N-[(E)-1-pyridin-2-ylethylideneamino]azetidine-1-carbothioamide
• InChI: InChI=1S/C11H14N4S/c1-9(10-5-2-3-6-12-10)13-14-11(16)15-7-4-8-15/h2-3,5-6H,4,7-8H2,1H3,(H,14,16)/b13-9+
• InChIKey: XDHBUMNIQRLHGO-UKTHLTGXSA-N
• SMILES: CC(=NNC(=S)N1CCC1)C2=CC=CC=N2

NSC 319726 (Cat No.:I004668) is an activator of p53(R175) mutant, inhibits the growth of cells expressing mutant p53, acts on p53(R175) mutant, IC50 is 8 nM, has no effect on p53 wild-type cells inhibition.

Reference

[1]. Yu X, et al. Allele-specific p53 mutant reactivation. Cancer Cell. 2012 May 15;21(5):614-25.