NSC305787 hydrochloride

• CAT Number: I003970
• CAS Number: 53868-26-1
• Molecular Formula: C25H31Cl3N2O
• Molecular Weight: 481.89
• Purity: ≥95%
• Target: PKC
• Solubility: DMSO: ≤ 8 mg/mL
• Storage: -20°C

NSC305787 hydrochloride is a small molecule inhibitor of PKC, with IC50 of 8.3 μM, 9.4 μM, 55 μM for PKCΙ phosphorylation of recombinant ezrin, of moesin, and of radixin.Target: PKCin vitro: NSC305787 demonstrates a novel targeted therapy that directly inhibits ezrin protein as an approach to prevent tumor metastasis. Both NSC305787 and NSC668394 inhibited T567 phosphorylation and actin binding of endogenous ezrin at 10 μM without altering cellular ezrin levels. Both NSC305787 (P = 0.003) significantly inhibits the lung metastases growth of high-ezrin-expressing K7M2 OS cells in this organ culture assay. [1]in vivo: NSC305787 cause reduced cell motility phenotypes in zebrafish. [1]

Reference

[1]. Bulut G, et al. Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells. Oncogene. 2012 Jan 19;31(3):269-281.