For research use only. Not for therapeutic Use.
NS3861 (Cat No.: I045637) is a small-molecule compound investigated as a research tool for modulating neuronal ion channel activity. It has been studied for its effects on voltage-gated sodium channels, which are critical for action potential generation and neuronal excitability. By altering sodium channel function, NS3861 is applied in preclinical research to explore mechanisms of epilepsy, neuropathic pain, and other excitability-related disorders. Though not developed for therapeutic application, NS3861 provides valuable insights into ion channel pharmacology and supports drug discovery in neurological disease research.
| CAS Number | 216853-59-7 |
| Synonyms | 3-(3-bromothiophen-2-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene |
| Molecular Formula | C12H14BrNS |
| Purity | ≥95% |
| InChI | InChI=1S/C12H14BrNS/c1-14-9-2-3-10(14)7-8(6-9)12-11(13)4-5-15-12/h4-6,9-10H,2-3,7H2,1H3 |
| InChIKey | ZJCNRVHZJADROC-UHFFFAOYSA-N |
| SMILES | CN1C2CCC1C=C(C2)C3=C(C=CS3)Br |
| Reference | [1]. Kasper Harpsøe, et al. Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. J Biol Chem. 2013 Jan 25;288(4):2559-70. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
