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BAM7

BAM7

  • CAT Number: I003191
  • CAS Number: 331244-89-4
  • Molecular Formula: C21H19N5O2S
  • Molecular Weight: 405.5
  • Purity: ≥95%
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BAM7（Cat No.:I003191）, is a compound used in tumor therapy. It functions as an activator of the pro-apoptotic protein BAX, promoting programmed cell death in cancer cells. BAM7 directly and selectively binds to BAX, triggering its apoptotic activity. With a potency indicated by a <BEC50<b> value of 3.3 μM, BAM7 shows potential as an effective agent for inducing apoptosis and combating tumors in therapeutic applications.

Catalog Number I003191
CAS Number 331244-89-4
Molecular Formula

C21H19N5O2S

Purity 95%
Target Apoptosis Inducers
Solubility 10 mM in DMSO (warmed)
Storage Store at -20°C
IC50 3.3 uM(EC50) [1]
IUPAC Name 4-[(2-ethoxyphenyl)diazenyl]-5-methyl-2-(4-phenyl-1,3-thiazol-2-yl)-1H-pyrazol-3-one
InChI InChI=1S/C21H19N5O2S/c1-3-28-18-12-8-7-11-16(18)23-24-19-14(2)25-26(20(19)27)21-22-17(13-29-21)15-9-5-4-6-10-15/h4-13,25H,3H2,1-2H3
InChIKey WRLVHADVOGFZOZ-UHFFFAOYSA-N
SMILES CCOC1=CC=CC=C1N=NC2=C(NN(C2=O)C3=NC(=CS3)C4=CC=CC=C4)C
Reference

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<br>[1]. Gavathiotis E, Reyna DE, Bellairs JA, Direct and selective small-molecule activation of proapoptotic BAX. Nat Chem Biol. 2012 Jul;8(7):639-45.

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