NS3728

• CAT Number: I008366
• CAS Number: 265646-85-3
• Molecular Formula: C16H9BrF6N6O
• Molecular Weight: 495.183
• Purity: ≥95%
• Target: ANO1 inhibitor
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 1-[3,5-bis(trifluoromethyl)phenyl]-3-[5-bromo-2-(2H-tetrazol-5-yl)phenyl]urea
• InChI: InChI=1S/C16H9BrF6N6O/c17-9-1-2-11(13-26-28-29-27-13)12(6-9)25-14(30)24-10-4-7(15(18,19)20)3-8(5-10)16(21,22)23/h1-6H,(H2,24,25,30)(H,26,27,28,29)
• InChIKey: OQRAKHDEGGGWQO-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C=C1Br)NC(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)C3=NNN=N3

NS3728 (CAT: I008366) is an inhibitor of ANO1 (Anoctamin 1), which is a calcium-activated chloride channel. ANO1 channels play a role in various physiological processes, including chloride ion transport and fluid secretion. Inhibition of ANO1 channels by NS3728 may have potential applications in research related to chloride channel function and associated biological processes. It’s important to note that further studies are needed to fully characterize the effects and potential therapeutic uses of ANO1 inhibitors like NS3728.

Reference

1: Sørensen BH, Nielsen D, Thorsteinsdottir UA, Hoffmann EK, Lambert IH. Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C857-73. doi: 10.1152/ajpcell.00256.2015. Epub 2016 Mar 16. PubMed PMID: 26984736; PubMed Central PMCID: PMC4935196.2: Sauter DR, Novak I, Pedersen SF, Larsen EH, Hoffmann EK. ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC). Pflugers Arch. 2015 Jul;467(7):1495-508. doi: 10.1007/s00424-014-1598-8. Epub 2014 Aug 28. PubMed PMID: 25163766; PubMed Central PMCID: PMC4464647.3: Poulsen KA, Andersen EC, Hansen CF, Klausen TK, Hougaard C, Lambert IH, Hoffmann EK. Deregulation of apoptotic volume decrease and ionic movements in multidrug-resistant tumor cells: role of chloride channels. Am J Physiol Cell Physiol. 2010 Jan;298(1):C14-25. doi: 10.1152/ajpcell.00654.2008. Epub 2009 Oct 21. PubMed PMID: 19846756.