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NS 3623

NS 3623

  • CAT Number: R042489
  • CAS Number: 343630-41-1
  • Molecular Formula: C15H10BrF3N6O
  • Molecular Weight: 427.185
  • Purity: ≥95%
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NS3623 is a KV11.1 (hERG) and KV4.3 channel activator. NS3623 activates the IKr and Ito currents and displays antiarrhythmic activity. NS3623 may also act as a partial blocker of KV11.1 channels. NS3623 is suitable for both in vitro and in vivo use.

Catalog Number R042489
CAS Number 343630-41-1
Molecular Formula

C15H10BrF3N6O

Purity 95%
Target Potassium Channel
Solubility Soluble in DMSO > 10 mM
Storage Store at +4C
IUPAC Name 1-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea
InChI InChI=1S/C15H10BrF3N6O/c16-9-4-5-12(11(7-9)13-22-24-25-23-13)21-14(26)20-10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H2,20,21,26)(H,22,23,24,25)
InChIKey JXPULDIATMTIIN-UHFFFAOYSA-N
SMILES C1=CC(=CC(=C1)NC(=O)NC2=C(C=C(C=C2)Br)C3=NNN=N3)C(F)(F)F
Reference

</br>1: Calloe K, Di Diego JM, Hansen RS, Nagle SA, Treat JA, Cordeiro JM. A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials. Biochem Pharmacol. 2016 May 15;108:36-46. doi: 10.1016/j.bcp.2016.03.015. Epub 2016 Mar 19. PubMed PMID: 27002181.</br>2: Larsen AP, Olesen SP, Grunnet M, Poelzing S. Pharmacological activation of IKr impairs conduction in guinea pig hearts. J Cardiovasc Electrophysiol. 2010 Aug 1;21(8):923-9. doi: 10.1111/j.1540-8167.2010.01733.x. Epub 2010 Feb 16. PubMed PMID: 20163495.</br>3: George AL Jr. Restoring repolarization in LQT3. Heart Rhythm. 2009 Jan;6(1):107-8. doi: 10.1016/j.hrthm.2008.10.037. Epub 2008 Oct 29. PubMed PMID: 19121809; PubMed Central PMCID: PMC2631665.</br></br>

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