NS-1619

• CAT Number: I001932
• CAS Number: 153587-01-0
• Molecular Formula: C15H8F6N2O2
• Molecular Weight: 362.23
• Purity: ≥95%
• Target: Potassium Channel
• Solubility: DMSO: ≥ 31 mg/mL
• Storage: 2-8°C
• IUPAC Name: 3-[2-hydroxy-5-(trifluoromethyl)phenyl]-6-(trifluoromethyl)-1H-benzimidazol-2-one
• InChI: InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
• InChIKey: YLFMCMWKHSDUCT-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C=C1C(F)(F)F)NC(=O)N2C3=C(C=CC(=C3)C(F)(F)F)O

NS-1619 is a compound that selectively activates large conductance Ca2+ -activated K+ (BK) channels. BK channels are found in various tissues and play important roles in regulating smooth muscle tone, neuronal excitability, and neurotransmitter release. NS-1619 binds to a specific site on the BK channel, leading to channel opening and subsequent hyperpolarization of the cell membrane.

Reference

1:The mitochondrial Ca2+-activated K+ channel activator, NS 1619 inhibits L-type Ca2+ channels in rat ventricular myocytes. Park WS, Kang SH, Son YK, Kim N, Ko JH, Kim HK, Ko EA, Kim CD, Han J.Biochem Biophys Res Commun. 2007 Oct 12;362(1):31-6. Epub 2007 Jul 23. PMID: 17698036 2:Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels. Calderone V, Martelli A, Testai L, Martinotti E, Breschi MC.Naunyn Schmiedebergs Arch Pharmacol. 2007 Mar;375(1):73-80. Epub 2007 Jan 4. PMID: 17203288 3:BK channel activation by NS-1619 is partially mediated by intracellular Ca2+ release in smooth muscle cells of porcine coronary artery. Yamamura H, Ohi Y, Muraki K, Watanabe M, Imaizumi Y.Br J Pharmacol. 2001 Feb;132(4):828-34. PMID: 11181423 Free PMC Article4:Inhibition of guinea pig detrusor contraction by NS-1619 is associated with activation of BKCa and inhibition of calcium currents. Sheldon JH, Norton NW, Argentieri TM.J Pharmacol Exp Ther. 1997 Dec;283(3):1193-200. PMID: 9399993 Free Article5:Differential effects of pinacidil, cromakalim, and NS 1619 on electrically evoked contractions in rat vas deferens. Huang Y, Lau CW.Zhongguo Yao Li Xue Bao. 1997 Jul;18(4):293-8. PMID: 10072907 Free Article6:NS 1619 activates Ca2+-activated K+ currents in rat vas deferens. Huang Y, Lau CW, Ho IH.Eur J Pharmacol. 1997 Apr 23;325(1):21-7. PMID: 9151934 7:A comparison of the effects of SCA40, NS 004 and NS 1619 on large conductance Ca(2+)-activated K+ channels in bovine tracheal smooth muscle cells in culture. Macmillan S, Sheridan RD, Chilvers ER, Patmore L.Br J Pharmacol. 1995 Sep;116(1):1656-60. PMID: 8564233 Free PMC Article8:NS 1619 activates BKCa channel activity in rat cortical neurones. Lee K, Rowe IC, Ashford ML.Eur J Pharmacol. 1995 Jul 4;280(2):215-9. PMID: 7589189 9:Ion channel modulation by NS 1619, the putative BKCa channel opener, in vascular smooth muscle. Edwards G, Niederste-Hollenberg A, Schneider J, Noack T, Weston AH.Br J Pharmacol. 1994 Dec;113(4):1538-47. PMID: 7534190 Free PMC Article10:Activation of BKCa channels in acutely dissociated neurones from the rat ventromedial hypothalamus by NS 1619. Sellers AJ, Ashford ML.Br J Pharmacol. 1994 Nov;113(3):659-61. PMID: 7858852 Free PMC Article