NQDI-1

• CAT Number: I002284
• CAS Number: 175026-96-7
• Molecular Formula: C₁₉H₁₃NO₄
• Molecular Weight: 319.31
• Purity: ≥95%
• Synonyms: ethyl 2,7-dioxo-3,7-dihydro-2H-naphtho[1,2,3-de]quinoline-1-carboxylate
• Target: ASK1
• Solubility: DMSO: ≤ 10 mg/mL
• Storage: Store at 4°C
• IC50: 500 nM (Ki) [1]
• InChI: InChI=1S/C19H13NO4/c1-2-24-19(23)16-15-10-6-3-4-7-11(10)17(21)12-8-5-9-13(14(12)15)20-18(16)22/h3-9H,2H2,1H3,(H,20,22)
• InChIKey: UFJGFNHRMPMALC-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1=C2C3=CC=CC=C3C(=O)C4=C2C(=CC=C4)NC1=O

NQDI-1 (CAT: I002284) is a small-molecule inhibitor that targets the interaction between the apoptosis signal-regulating kinase 1 (ASK1) and its regulatory protein, thioredoxin. By disrupting this interaction, NQDI-1 inhibits the activation of ASK1, which is involved in cellular stress responses and inflammation. NQDI-1 has shown potential in various disease models, including neurodegenerative diseases, ischemic injury, and inflammation-related disorders. It is known for its ability to reduce oxidative stress, promote cell survival, and attenuate inflammatory responses. NQDI-1 represents a promising tool for further understanding the role of ASK1 signaling and may have therapeutic applications in treating certain diseases associated with oxidative stress and inflammation.

Reference

1:NQDI-1, an inhibitor of ASK1 attenuates acute perinatal hypoxic-ischemic cerebral injury by modulating cell death. Hao H, Li S, Tang H, Liu B, Cai Y, Shi C, Xiao X.Mol Med Rep. 2016 Jun;13(6):4585-92. doi: 10.3892/mmr.2016.5123. Epub 2016 Apr 13. PMID: 27081917 Free PMC Article2:NQDI 1, an inhibitor of ASK1 attenuates acute ischemic renal injury by modulating oxidative stress and cell death. El Eter E.Cardiovasc Hematol Agents Med Chem. 2013 Sep;11(3):179-86. PMID: 23952292