Nosiheptide

• CAT Number: R017657
• CAS Number: 56377-79-8
• Molecular Formula: C51H43N13O12S6
• Molecular Weight: 1222.4
• Purity: ≥95%
• Storage: -20°C
• InChIKey: OQAOHXRUMXWDLQ-OIHXUFRMSA-N
• SMILES: OC1=C(C2=NC(C(NC(C(N)=O)=C)=O)=CS2)N=C(C3=CSC([C@](NC(C4=CSC([C@](NC(C5=CSC(/C(NC([C@](NC(C6=CSC7=N6)=O)([H])[C@@H](O)C)=O)=C/C)=N5)=O)([H])C[C@H](O)C(OC8)=O)=N4)=O)([H])CSC(C9=C(C)C(C8=CC=C%10)=C%10N9)=O)=N3)C7=C1

A bicyclic thiopeptide antibiotic produced by several species of actinomycetes, notably streptomyces; has broad spectrum antibacterial activity; demonstrated a prolonged post-antibiotic effect in both nosocomial and community-acquired MRSA compared with vancomycin

Reference

A new antibiotic, multhiomycin. Tanaka T. et al. J. Antibiot. 1970, 23, 231.

Identity of multhiomycin with nosiheptide. Endo T. and Yonehara H. J. Antibiot, 1978, 31, 623.

Thiostrepton group of antibiotics. Pestka S. and Bodley J. Antibiotics. III. 1975, 551-573 ed. Corcoran J.W. & Harn F.E., Springer-Verlag, New York.

Activity of the thiopeptide antibiotic, nosiheptide, against contemporary strains of methicillin-resistant Staphylococcus aureus. Haste N.M. et al. J. Antibiot. 2012, 65, 593.