Norepinephrine

• CAT Number: I008327
• CAS Number: 51-41-2
• Molecular Formula: C8H11NO3
• Molecular Weight: 169.18
• Purity: ≥95%
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
• InChI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
• InChIKey: SFLSHLFXELFNJZ-QMMMGPOBSA-N
• SMILES: C1=CC(=C(C=C1C(CN)O)O)O

Norepinephrine is an organic chemical in the catecholamine family that functions in the human brain and body as a hormone and neurotransmitter. Norepinephrine directly stimulates adrenergic receptors. Stimulation of alpha-adrenergic receptors causes vasoconstriction of the radial smooth muscle of the iris, arteries, arterioles, veins, urinary bladder, and the sphincter of the gastrointestinal tract. Stimulation of beta-1 adrenergic receptors causes an increase in myocardial contractility, heart rate, automaticity, and atrioventricular (AV) conduction while stimulation of beta-2 adrenergic receptors causes bronchiolar and vascular smooth muscle dilatation.

Reference

1:Differences in neurohumoral and hemodynamic response to prolonged head-up tilt between patients with high and normal standing norepinephrine forms of postural orthostatic tachycardia syndrome. Crnošija L, Krbot Skorić M, Lovrić M, Junaković A, Miletić V, Alfirev RŠ, Pavelić A, Adamec I, Habek M.Auton Neurosci. 2017 May 11. pii: S1566-0702(16)30310-1. doi: 10.1016/j.autneu.2017.05.007. [Epub ahead of print] PMID: 28522107 2:Norepinephrine in septic shock: when and how much? Hamzaoui O, Scheeren TWL, Teboul JL.Curr Opin Crit Care. 2017 May 13. doi: 10.1097/MCC.0000000000000418. [Epub ahead of print] PMID: 28509668 3:Effects of α2A Adrenoceptors on Norepinephrine Secretion from the Locus Coeruleus during Chronic Stress-Induced Depression. Wang B, Wang Y, Wu Q, Huang HP, Li S.Front Neurosci. 2017 May 1;11:243. doi: 10.3389/fnins.2017.00243. eCollection 2017. PMID: 28507504 Free PMC Article4:Serotonin-norepinephrine reuptake inhibitors and the influence of binding affinity (Ki) on analgesia. Raouf M, Glogowski AJ, Bettinger JJ, Fudin J.J Clin Pharm Ther. 2017 May 15. doi: 10.1111/jcpt.12534. [Epub ahead of print] PMID: 28503727 5:Norepinephrine stimulation of alpha1D-adrenoceptor promotes proliferation of pulmonary artery smooth muscle cells via ERK-1/2 signaling. Liu R, Zhang Q, Luo Q, Qiao H, Wang P, Yu J, Cao Y, Lu B, Qu L.Int J Biochem Cell Biol. 2017 May 2;88:100-112. doi: 10.1016/j.biocel.2017.05.001. [Epub ahead of print] PMID: 28476501 6:miR-21 is involved in norepinephrine-mediated rat granulosa cell apoptosis by targeting SMAD7. Zhang L, Gao J, Cui S.J Mol Endocrinol. 2017 May;58(4):199-210. doi: 10.1530/JME-16-0248. PMID: 28473352 7:Erratum to: Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine. Mehta S, Granton J, Gordon AC, Cook DJ, Lapinsky S, Newton G, Bandayrel K, Little A, Siau C, Ayers D, Singer J, Lee TCK, Walley KR, Storms M, Cooper DJ, Holmes CL, Hebert P, Presneill J, Russell JA; Vasopressin and Septic Shock Trial (VASST) Investigators..Crit Care. 2017 May 4;21(1):98. doi: 10.1186/s13054-017-1680-7. No abstract available. PMID: 28468661 Free PMC Article8:[The predictive value of dynamic arterial elastance in arterial pressure response after norepinephrine dosage reduction in patients with septic shock]. Liang FM, Yang T, Dong L, Hui JJ, Yan J.Zhonghua Nei Ke Za Zhi. 2017 May 1;56(5):344-348. doi: 10.3760/cma.j.issn.0578-1426.2017.05.008. Chinese. PMID: 28460504 9:Mechanisms underlying alterations in norepinephrine levels in the locus coeruleus of ovariectomized rats: Modulation by estradiol valerate and black cohosh. Zhang J, Bai W, Wang W, Jiang H, Jin B, Liu Y, Liu S, Wang K, Jia J, Qin L.Neuroscience. 2017 Apr 27;354:110-121. doi: 10.1016/j.neuroscience.2017.04.029. [Epub ahead of print] PMID: 28457819 10:Effects of Dopamine and Norepinephrine on Exercise-induced Oculomotor Fatigue. Connell CJW, Thompson B, Turuwhenua J, Srzich A, Gant N.Med Sci Sports Exerc. 2017 Apr 28. doi: 10.1249/MSS.0000000000001307. [Epub ahead of print] PMID: 28452866