nor-NOHA monoacetate

• CAT Number: I015053
• CAS Number: 2250019-93-1
• Molecular Formula: C7H16N4O5
• Molecular Weight: 236.23
• Purity: ≥95%
• Synonyms: acetic acid;(2S)-2-amino-4-[[amino-(hydroxyamino)methylidene]amino]butanoic acid
• InChI: InChI=1S/C5H12N4O3.C2H4O2/c6-3(4(10)11)1-2-8-5(7)9-12;1-2(3)4/h3,12H,1-2,6H2,(H,10,11)(H3,7,8,9);1H3,(H,3,4)/t3-;/m0./s1
• InChIKey: RYUGHGOGNIYFKU-DFWYDOINSA-N
• SMILES: CC(=O)O.C(CN=C(N)NO)[C@@H](C(=O)O)N

nor-NOHA monoacetate（Cat No.:I015053） is a prodrug form of N^ω-hydroxy-nor-L-arginine (nor-NOHA), a potent and selective inhibitor of arginase enzymes (Arg1 and Arg2). By blocking arginase activity, it increases L-arginine availability, thereby enhancing nitric oxide (NO) production and modulating vascular tone, immune responses, and cellular metabolism. nor-NOHA monoacetate is more stable and cell-permeable than nor-NOHA, making it useful for in vitro and in vivo studies. It has applications in cardiovascular, cancer, and immunology research, particularly in exploring pathways linking arginase activity to endothelial dysfunction and tumor progression.