KC7F2

• CAT Number: I005516
• CAS Number: 927822-86-4
• Molecular Formula: C₁₆H₁₆Cl₄N₂O₄S₄
• Molecular Weight: 570.38
• Purity: ≥95%
• Target: HIF
• Solubility: DMSO: ≥ 32 mg/mL
• Storage: Store at -20°C
• InChI: InChI=1S/C16H16Cl4N2O4S4/c17-11-1-3-13(19)15(9-11)29(23,24)21-5-7-27-28-8-6-22-30(25,26)16-10-12(18)2-4-14(16)20/h1-4,9-10,21-22H,5-8H2
• InChIKey: REQLACDIZMLXIC-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C=C1Cl)S(=O)(=O)NCCSSCCNS(=O)(=O)C2=C(C=CC(=C2)Cl)Cl)Cl

KC7F2(cat: I005516) is a compound known for its inhibitory effects on the hypoxia-inducible factor-1 (HIF-1) pathway. HIF-1 is a transcription factor that plays a crucial role in cellular responses to hypoxia (low oxygen levels) and is implicated in various aspects of cancer progression and metastasis. KC7F2 has demonstrated potent inhibitory activity against the HIF-1 pathway, potentially interfering with the activation of genes involved in tumor growth and angiogenesis.

Reference

[1]. Narita T, et al. Identification of a novel small molecule HIF-1alpha translation inhibitor. Clin Cancer Res. 2009 Oct 1;15(19):6128-6136.


[2]. Koh MY, et al. Inhibiting the hypoxia response for cancer therapy: the new kid on the block. Clin Cancer Res. 2009 Oct 1;15(19):5945-5946.