Nonivamide

• CAT Number: I002822
• CAS Number: 2444-46-4
• Molecular Formula: C17H27NO3
• Molecular Weight: 293.4
• Purity: ≥95%
• Target: TRP Channel
• Solubility: 10 mM in DMSO
• Storage: 2-8°C
• IUPAC Name: N-[(4-hydroxy-3-methoxyphenyl)methyl]nonanamide
• InChI: InChI=1S/C17H27NO3/c1-3-4-5-6-7-8-9-17(20)18-13-14-10-11-15(19)16(12-14)21-2/h10-12,19H,3-9,13H2,1-2H3,(H,18,20)
• InChIKey: RGOVYLWUIBMPGK-UHFFFAOYSA-N
• SMILES: CCCCCCCCC(=O)NCC1=CC(=C(C=C1)O)OC

Nonivamide（Cat No.:I002822） is a naturally occurring analog of capsaicin, derived from peppers. It shares similarities with capsaicin in terms of its effects and acts as an agonist of the VR1 receptor, also known as TRPV1 (transient receptor potential vanilloid 1). Like capsaicin, nonivamide can elicit sensations of heat and pain when applied to sensory nerve endings, activating the TRPV1 receptor. This natural compound provides a valuable tool for studying the physiological and pharmacological properties of TRPV1 and its involvement in pain perception and sensory processing.

Reference

[1]. Skofitsch G, et al. Comparison of nonivamide and capsaicin with regard to their pharmacokinetics and effects on sensory neurons. Arzneimittelforschung. 1984;34(2):154-6.
[2]. Hayes AG, et al. The effects of a series of capsaicin analogues on nociception and body temperature in the rat. Life Sci. 1984 Mar 26;34(13):1241-8.
[3]. Suzuki T, et al. A possible role of nitric oxide formation in the vasodilatation of rabbit ear artery induced by a topically applied Capsaicin analogue. J Vet Med Sci. 1998 Jun;60(6):691-7.
[4]. Thomas KC, et al. Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells. J Pharmacol Exp Ther. 2007 Jun;321(3):830-8.