Nobiletin

• CAT Number: I003671
• CAS Number: 478-01-3
• Molecular Formula: C21H22O8
• Molecular Weight: 402.4
• Purity: ≥95%
• Target: MMP
• Solubility: DMSO: ≥ 31 mg/mL
• Storage: 3 years -20℃ powder
• IUPAC Name: 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
• InChI: InChI=1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3
• InChIKey: MRIAQLRQZPPODS-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC)OC

Nobiletin (Cat.No:I003671) is a natural flavonoid compound found in citrus fruits, particularly in the peels of tangerines and oranges. Known for its various health benefits, nobiletin exhibits antioxidant, anti-inflammatory, and anticancer properties. It has shown potential in the prevention and treatment of conditions such as cancer, cardiovascular diseases, and neurodegenerative disorders. Ongoing research continues to unveil its therapeutic potential.

Reference

[1]. Takito J, et al. Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells. Can J Physiol Pharmacol. 2016 Feb 12:1-6.
[2]. He B, et al. The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome. Cell Metab. 2016 Apr 12;23(4):610-21.
[3]. Cheng HL, et al. Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression. Oncotarget. 2016 Apr 29.