NMS-1286937

• CAT Number: I000207
• CAS Number: 1034616-18-6
• Molecular Formula: C24H27F3N8O3
• Molecular Weight: 532.52
• Purity: ≥95%
• Target: PLK
• Solubility: DMSO: ≥ 21 mg/mL
• Storage: Store at -20°C
• IC50: 2 nM [1]
• IUPAC Name: 1-(2-hydroxyethyl)-8-[5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)anilino]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide Computed by Lexichem TK 2.7.0 (PubChem release 2021.05.07)
• InChI: InChI=1S/C24H27F3N8O3/c1-33-6-8-34(9-7-33)15-3-5-18(38-24(25,26)27)17(12-15)30-23-29-13-14-2-4-16-20(22(28)37)32-35(10-11-36)21(16)19(14)31-23/h3,5,12-13,36H,2,4,6-11H2,1H3,(H2,28,37)(H,29,30,31)
• InChIKey: QHLVBNKYJGBCQJ-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)C2=CC(=C(C=C2)OC(F)(F)F)NC3=NC=C4CCC5=C(C4=N3)N(N=C5C(=O)N)CCO

NMS-1286937 (Cat.No:I000207) is a potent and selective inhibitor used in cancer research. It targets the Aurora kinase family, particularly Aurora A and B, which play crucial roles in cell division and proliferation. Preclinical studies have shown promising anti-tumor activity, making NMS-1286937 a potential candidate for the development of novel cancer therapies.

Reference

[1]. Beria I, et al. NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor. Bioorg Med Chem Lett. 2011 May 15;21(10):2969-74.
[2]. Valsasina B, et al. NMS-P937, an orally available, specific small-molecule polo-like kinase 1 inhibitor with antitumor activity in solid and hematologic malignancies. Mol Cancer Ther. 2012 Apr;11(4):1006-16.
[3]. Casolaro A, et al. The Polo-Like Kinase 1 (PLK1) inhibitor NMS-P937 is effective in a new model of disseminated primary CD56+ acute monoblastic leukaemia. PLoS One. 2013;8(3):e58424.