NMDA

• CAT Number: I004411
• CAS Number: 6384-92-5
• Molecular Formula: C5H9NO4
• Molecular Weight: 147.1
• Purity: ≥95%
• Synonyms: (2R)-2-(methylamino)butanedioic acid
• Target: GluR
• Solubility: H2O: 30 mg/mL, DMSO: 5 mg/mL
• Storage: 3 years -20C powder
• InChIKey: HOKKHZGPKSLGJE-GSVOUGTGSA-N

NMDA(N-Methyl-D-aspartic acid) is an amino acid derivative that acts as a specific agonist at the NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.IC50 value:Target: NMDA receptorNMDA is a water-soluble synthetic substance that is not normally found in biological tissue. It was first synthesized in the 1960s. NMDA is an excitotoxin (it kills nerve cells by over-exciting them); this trait has applications in behavioral neuroscience research. The body of work utilizing this technique falls under the term /lesion studies/. Researchers apply NMDA to specific regions of an (animal) subject/’s brain or spinal cord and subsequently test for the behavior of interest, such as operant behavior. If the behavior is compromised, it suggests the destroyed tissue was part of a brain region that made an important contribution to the normal expression of that behavior. The mechanism of stimulating NMDA receptor is a specific agonist-binding to its NR2 subunits, and then a non-specific cation channel is opened, which can allow the passage of Ca2+ and Na+ into the cell and K+ out of the cell. The excitatory postsynaptic potential (EPSP) produced by activation of an NMDA receptor also increases the concentration of Ca2+ in the cell. The Ca2+ can in turn function as a second messenger in various signaling pathways. [1][2][3]

Reference

[1]. Dingledine R, et al. The glutamate receptor ion channels. Pharmacol Rev. 1999 Mar;51(1):7-61.
[2]. Liu Y, et al. Recent development in NMDA receptors. Chin Med J (Engl). 2000 Oct;113(10):948-56.
[3]. Cull-Candy S, et al. NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol. 2001 Jun;11(3):327-35.