Nintedanib-d8

• CAT Number: R031105
• CAS Number: 1624587-87-6
• Molecular Formula: C31H25D8N5O4
• Molecular Weight: 547.67
• Purity: ≥95%
• Synonyms: methyl 2-hydroxy-3-[N-[4-[methyl-[2-(2,2,3,3,5,5,6,6-octadeuterio-4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate
• InChI: InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,33,38H,15-18,20H2,1-3H3/i15D2,16D2,17D2,18D2
• InChIKey: CPMDPSXJELVGJG-BVUACPEDSA-N
• SMILES: [2H]C1(C(N(C(C(N1C)([2H])[2H])([2H])[2H])CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O)([2H])[2H])[2H]

Nintedanib-d8（Cat No.:R031105）is a deuterated form of nintedanib, a multi-kinase inhibitor used primarily in the treatment of idiopathic pulmonary fibrosis and certain types of cancer. The “d8” label indicates the incorporation of eight deuterium atoms, a stable isotope of hydrogen, replacing the hydrogen atoms in the molecule. This modification is used in pharmacokinetic studies to track the metabolism and pharmacodynamics of nintedanib. Nintedanib-d8 helps researchers evaluate the drug’s bioavailability, clearance, and tissue distribution, providing valuable insights into its behavior in the body and improving drug development processes.