NIH-12848

• CAT Number: I008180
• CAS Number: 959551-10-1
• Molecular Formula: C20H14F3N3S
• Molecular Weight: 385.4082
• Purity: ≥95%
• Target: PI5P4Kγ) inhibitor
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• InChI: InChI=1S/C20H14F3N3S/c21-20(22,23)16-9-3-1-7-14(16)19-25-17-10-4-2-8-15(17)18(26-19)24-12-13-6-5-11-27-13/h1-11H,12H2,(H,24,25,26)
• InChIKey: QBDAEJRHUCSSPR-UHFFFAOYSA-N
• SMILES: FC(F)(F)C(C=CC=C1)=C1C2=NC3=CC=CC=C3C(NCC4=CC=CS4)=N2

NIH-12848(CAT: I008180) is a compound that has been identified as a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ). PI5P4Kγ is an enzyme involved in the regulation of cellular signaling pathways by phosphorylating phosphatidylinositol 5-phosphate (PI5P) to generate phosphatidylinositol 4,5-bisphosphate (PIP2). Inhibition of PI5P4Kγ may modulate PIP2 levels and disrupt downstream signaling cascades.

Reference

1:Clarke JH, Giudici ML, Burke JE, Williams RL, Maloney DJ, Marugan J, Irvine RF. The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site. Biochem J. 2015 Mar 1;466(2):359-67. doi: 10.1042/BJ20141333. PubMed PMID: 25495341; PubMed Central PMCID: PMC4687057.