Nifedipine

• CAT Number: A000736
• CAS Number: 21829-25-4
• Molecular Formula: C17H18N2O6
• Molecular Weight: 346.3
• Purity: ≥95%
• Synonyms: 21829-25-4; Procardia; Adalat; Procardia XL; Adalat CC
• Storage: -20°C
• InChI: 1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
• InChIKey: HYIMSNHJOBLJNT-UHFFFAOYSA-N
• SMILES: CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC

a L-type Ca2+ channels blocker; antihypertensive.


Dihydropyridine derivative,<!–C17H18N2O6–>, synthetic.

Inhibits L-type Ca2+ channels in chick sensory neurons [4].
Antihypertensive; vasodilator; antianginal.
Has teratogenic effect on some animal species

Reference

1: Hu H, Zhang J, Wang Y, Tian Z, Liu D, Zhang G, Gu G, Zheng H, Xie R, Cui W.
Impact of baseline blood pressure on the magnitude of blood pressure lowering by
nifedipine gastrointestinal therapeutic system: refreshing the Wilder/’s
principle. Drug Des Devel Ther. 2017 Nov 6;11:3179-3186. doi:
10.2147/DDDT.S143551. eCollection 2017. PubMed PMID: 29158664; PubMed Central
PMCID: PMC5683797.

2: Bolnick AD, Bolnick JM, Kohan-Ghadr HR, Kilburn BA, Hertz M, Dai J, Drewlo S,
Armant DR. Nifedipine prevents apoptosis of alcohol-exposed first trimester
trophoblast cells. Alcohol Clin Exp Res. 2017 Oct 19. doi: 10.1111/acer.13534.
[Epub ahead of print] PubMed PMID: 29048755.

3: Ding J, Kang Y, Fan Y, Chen Q. Efficacy of resveratrol to supplement oral
nifedipine treatment in pregnancy-induced preeclampsia. Endocr Connect. 2017
Nov;6(8):595-600. doi: 10.1530/EC-17-0130. PubMed PMID: 28993436; PubMed Central
PMCID: PMC5633060.

4: Rahul M, Piyoosh S, Tekade M, Atneriya U, Dua K, Hansbroe PM, Tekade RK.
Microsponge embedded tablet for sustained delivery of nifedipine. Pharm
Nanotechnol. 2017 Sep 21. doi: 10.2174/2211738505666170921125549. [Epub ahead of
print] PubMed PMID: 28933273.

5: Webster LM, Myers JE, Nelson-Piercy C, Harding K, Cruickshank JK, Watt-Coote
I, Khalil A, Wiesender C, Seed PT, Chappell LC. Labetalol Versus Nifedipine as
Antihypertensive Treatment for Chronic Hypertension in Pregnancy: A Randomized
Controlled Trial. Hypertension. 2017 Nov;70(5):915-922. doi:
10.1161/HYPERTENSIONAHA.117.09972. Epub 2017 Sep 11. PubMed PMID: 28893900.

6: Sharma C, Soni A, Gupta A, Verma A, Verma S. Hydralazine vs nifedipine for
acute hypertensive emergency in pregnancy: a randomized controlled trial. Am J
Obstet Gynecol. 2017 Sep 1. pii: S0002-9378(17)30965-1. doi:
10.1016/j.ajog.2017.08.018. [Epub ahead of print] PubMed PMID: 28867601.

7: Shah SP, Self TH, Bradsher RW 3rd, Owens RE. Clarithromycin-nifedipine-induced
acute kidney injury. Nurse Pract. 2017 Sep 21;42(9):49-51. doi:
10.1097/01.NPR.0000521991.15440.a7. PubMed PMID: 28832423.

8: Aggarwal A, Bagga R, Girish B, Kalra J, Kumar P. Effect of maintenance
tocolysis with nifedipine in established preterm labour on pregnancy prolongation
and neonatal outcome. J Obstet Gynaecol. 2017 Aug 8:1-8. doi:
10.1080/01443615.2017.1331340. [Epub ahead of print] PubMed PMID: 28784001.

9: Xiao S, Zhang M, Liang Y, Wang D. Celastrol synergizes with oral nifedipine to
attenuate hypertension in preeclampsia: a randomized, placebo-controlled, and
double blinded trial. J Am Soc Hypertens. 2017 Sep;11(9):598-603. doi:
10.1016/j.jash.2017.07.004. Epub 2017 Jul 20. PubMed PMID: 28757108.

10: Shi DD, Guo JJ, Zhou L, Wang N. Epigallocatechin gallate enhances treatment
efficacy of oral nifedipine against pregnancy-induced severe pre-eclampsia: A
double-blind, randomized and placebo-controlled clinical study. J Clin Pharm
Ther. 2017 Jul 20. doi: 10.1111/jcpt.12597. [Epub ahead of print] PubMed PMID:
28726273.