Nidufexor

• CAT Number: I019418
• CAS Number: 1773489-72-7
• Molecular Formula: C₂₇H₂₂ClN₃O₄
• Molecular Weight: 487.93
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 4-[[benzyl-(8-chloro-1-methyl-4H-chromeno[4,3-c]pyrazole-3-carbonyl)amino]methyl]benzoic acid
• InChI: InChI=1S/C27H22ClN3O4/c1-30-25-21-13-20(28)11-12-23(21)35-16-22(25)24(29-30)26(32)31(14-17-5-3-2-4-6-17)15-18-7-9-19(10-8-18)27(33)34/h2-13H,14-16H2,1H3,(H,33,34)
• InChIKey: JYTIXGYXBIBOMN-UHFFFAOYSA-N
• SMILES: CN1C2=C(COC3=C2C=C(C=C3)Cl)C(=N1)C(=O)N(CC4=CC=CC=C4)CC5=CC=C(C=C5)C(=O)O

Nidufexor (Cat No.:I019418) is an agonist of the farnesoid X receptor (FXR). As an agonist, it activates the FXR, a nuclear receptor involved in the regulation of various metabolic processes. By binding to and activating FXR, nidufexor modulates gene expression related to bile acid homeostasis, lipid metabolism, and inflammation. This activation of FXR has the potential to be therapeutically beneficial, particularly in the treatment of liver diseases such as non-alcoholic steatohepatitis (NASH) and primary biliary cholangitis (PBC).

Reference

[1]. Chianelli D, et al. Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2020 Apr 23;63(8):3868-3880.