For research use only. Not for therapeutic Use.
NIBR0213（Cat No.:I008287）is a selective and potent antagonist of the sphingosine-1-phosphate receptor 1 (S1P₁), a G protein-coupled receptor involved in immune cell trafficking and vascular integrity. By blocking S1P₁ signaling, NIBR0213 prevents lymphocyte egress from lymphoid tissues, thereby reducing peripheral inflammation. It has been studied in preclinical models of autoimmune diseases such as multiple sclerosis and inflammatory bowel disease. Unlike functional antagonists that cause receptor internalization, NIBR0213 acts through competitive binding. It is a valuable tool for dissecting S1P₁-mediated pathways.
| CAS Number | 1233332-14-3 |
| Synonyms | (2S)-2-[[4-[3-[[(1R)-1-(4-chloro-3-methylphenyl)ethyl]amino]phenyl]-2,6-dimethylbenzoyl]amino]propanoic acid |
| Molecular Formula | C27H29ClN2O3 |
| Purity | ≥95% |
| IUPAC Name | (2S)-2-[[4-[3-[[(1R)-1-(4-chloro-3-methylphenyl)ethyl]amino]phenyl]-2,6-dimethylbenzoyl]amino]propanoic acid |
| InChI | InChI=1S/C27H29ClN2O3/c1-15-11-20(9-10-24(15)28)18(4)29-23-8-6-7-21(14-23)22-12-16(2)25(17(3)13-22)26(31)30-19(5)27(32)33/h6-14,18-19,29H,1-5H3,(H,30,31)(H,32,33)/t18-,19+/m1/s1 |
| InChIKey | KYHUARFFBDLROH-MOPGFXCFSA-N |
| SMILES | CC1=CC(=CC(=C1C(=O)N[C@@H](C)C(=O)O)C)C2=CC(=CC=C2)N[C@H](C)C3=CC(=C(C=C3)Cl)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
