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Endoxifen Z-isomer

Endoxifen Z-isomer

  • CAT Number: I000461
  • CAS Number: 112093-28-4
  • Molecular Formula: C25H27NO2
  • Molecular Weight: 373.49
  • Purity: ≥95%
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The Endoxifen (Cat.No:I000461) is an active metabolite of tamoxifen, a commonly used medication for breast cancer treatment. Endoxifen Z-isomer exhibits potent anti-estrogenic effects by selectively binding to estrogen receptors. It holds promise as a therapeutic agent for hormone receptor-positive breast cancer, contributing to improved patient outcomes.

Catalog Number I000461
CAS Number 112093-28-4
Molecular Formula

C25H27NO2

Purity 95%
Target Estrogen/progestogen Receptor
Solubility 10 mM in DMSO
Storage Store at 4℃
IC50 1.6 μM [1]
IUPAC Name 4-[(Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
InChI InChI=1S/C25H27NO2/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2/h4-16,26-27H,3,17-18H2,1-2H3/b25-24-
InChIKey MHJBZVSGOZTKRH-IZHYLOQSSA-N
SMILES CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCNC)C3=CC=CC=C3
Reference

<p style=/line-height:25px/>
<br>[1]. Chae YJ, et al. Endoxifen, the active metabolite of tamoxifen, inhibits cloned hERG potassium channels. Eur J Pharmacol. 2015 Apr 5;752:1-7.
<br>[2]. Wu X, et al. Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen. Breast Cancer Res. 2011 Mar 10;13(2):R27.
</p>

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