NGI-1

• CAT Number: I011968
• CAS Number: 790702-57-7
• Molecular Formula: C17H22N4O3S2
• Molecular Weight: 394.51
• Purity: ≥95%
• Synonyms: NGI-1; NGI1; NGI 1; ML414; ML 414; ML-414;5-(dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide
• Target: OST inhibitor
• Solubility: Soluble in DMSO
• Storage: 2-8°C
• IUPAC Name: 5-(dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-pyrrolidin-1-ylbenzamide
• InChI: InChI=1S/C17H22N4O3S2/c1-12-11-18-17(25-12)19-16(22)14-10-13(26(23,24)20(2)3)6-7-15(14)21-8-4-5-9-21/h6-7,10-11H,4-5,8-9H2,1-3H3,(H,18,19,22)
• InChIKey: QPKGRLIYJGBKJL-UHFFFAOYSA-N
• SMILES: CC1=CN=C(S1)NC(=O)C2=C(C=CC(=C2)S(=O)(=O)N(C)C)N3CCCC3

NGI-1 (Cat No.:I011968) is a reversible inhibitor of the catalytic subunit of oligosaccharyltransferase (OST), with higher specificity for STT3B than STT3A (STT: OST catalytic subunit). In non-small cell lung cancer cells, NGI-1 prevents cell surface localization and signaling of the EGFR glycoprotein but has a proliferation arrest effect only on those cell lines that depend on EGFR (or FGFR) for survival.

Reference

1: Lopez-Sambrooks C, Shrimal S, Khodier C, Flaherty DP, Rinis N, Charest JC, Gao N, Zhao P, Wells L, Lewis TA, Lehrman MA, Gilmore R, Golden JE, Contessa JN. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol. 2016 Dec;12(12):1023-1030. doi: 10.1038/nchembio.2194. Epub 2016 Oct 3. PubMed PMID: 27694802; PubMed Central PMCID: PMC5393272.