Nemifitide diTFA

• CAT Number: I017260
• CAS Number: 204992-09-6
• Molecular Formula: C37H45F7N10O10
• Molecular Weight: 922.80
• Purity: ≥95%
• Synonyms: (2S,4R)-1-[(2S)-2-amino-3-(4-fluorophenyl)propanoyl]-N-[(2S)-1-[[2-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-hydroxypyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C33H43FN10O6.2C2HF3O2/c34-20-9-7-18(8-10-20)12-23(35)32(50)44-17-21(45)14-27(44)31(49)43-25(6-3-11-39-33(37)38)30(48)41-16-28(46)42-26(29(36)47)13-19-15-40-24-5-2-1-4-22(19)24;2*3-2(4,5)1(6)7/h1-2,4-5,7-10,15,21,23,25-27,40,45H,3,6,11-14,16-17,35H2,(H2,36,47)(H,41,48)(H,42,46)(H,43,49)(H4,37,38,39);2*(H,6,7)/t21-,23+,25+,26+,27+;;/m1../s1
• InChIKey: QXCFOJXOLMOPRK-QOXNQHIRSA-N
• SMILES: C1C(CN(C1C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)C(=O)C(CC4=CC=C(C=C4)F)N)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O

Nemifitide diTFA(CAT: I017260) is a synthetic pentapeptide antidepressant candidate that acts as a modulator of monoaminergic neurotransmission. Originally developed for the treatment of major depressive disorder (MDD), Nemifitide demonstrated rapid-acting antidepressant effects in early clinical studies, distinct from conventional SSRIs and tricyclic antidepressants. Its mechanism of action is thought to involve modulation of serotonergic and dopaminergic pathways, contributing to enhanced mood regulation. While its clinical development was discontinued, Nemifitide remains a valuable research tool for investigating novel peptide-based approaches to depression, central nervous system (CNS) signaling, and neuropsychiatric disease mechanisms.