Nelfinavir

• CAT Number: I002032
• CAS Number: 159989-64-7
• Molecular Formula: C32H45N3O4S
• Molecular Weight: 567.78
• Purity: ≥95%
• Target: HIV Integrase
• Solubility: 10 mM in DMSO
• Storage: Store at -20C
• IC50: 2 nM (Ki for HIV-1 protease)
• IUPAC Name: (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide
• InChI: InChI=1S/C32H45N3O4S/c1-21-25(15-10-16-28(21)36)30(38)33-26(20-40-24-13-6-5-7-14-24)29(37)19-35-18-23-12-9-8-11-22(23)17-27(35)31(39)34-32(2,3)4/h5-7,10,13-16,22-23,26-27,29,36-37H,8-9,11-12,17-20H2,1-4H3,(H,33,38)(H,34,39)/t22-,23+,26-,27-,29+/m0/s1
• InChIKey: QAGYKUNXZHXKMR-HKWSIXNMSA-N
• SMILES: CC1=C(C=CC=C1O)C(=O)NC(CSC2=CC=CC=C2)C(CN3CC4CCCCC4CC3C(=O)NC(C)(C)C)O

Nelfinavir (CAT: I002032) is an antiretroviral medication that belongs to the class of drugs known as protease inhibitors. It is primarily used for the treatment of HIV infection. Nelfinavir works by inhibiting the protease enzyme, which is responsible for the cleavage of viral polyproteins into functional proteins needed for the replication of HIV. By blocking this enzyme, nelfinavir helps to reduce the viral load and slow down the progression of HIV infection. Additionally, nelfinavir has also been investigated for its potential in the treatment of certain cancers due to its ability to inhibit various cellular pathways involved in tumor growth and survival.

Overview of Clinical Research

Nelfinavir is a virus replication inhibitor. No recent reports of development identified for preclinical development in Severe acute respiratory syndrome in Japan (PO).

Reference

1. Mondal D, et al. Nelfinavir suppresses insulin signaling and nitric oxide production by human aortic endothelial cells: protective effects of thiazolidinediones. Ochsner J. 2013 Spring;13(1):76-90.
2. Kaldor SW, et al. Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease. J Med Chem. 1997 Nov 21;40(24):3979-85.