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Nebivolol

Nebivolol

  • CAT Number: A000550
  • CAS Number: 152520-56-4
  • Molecular Formula: C22H26ClF2NO4
  • Molecular Weight: 441.9
  • Purity: ≥95%
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Nebivolol HCl selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM.<br>Nebivolol shows high affinity and selectivity for beta 1-adrenergic receptor sites in a rabbit lung membrane preparation (K<sub>i</sub> value = 0.9 nM and beta 2/beta 1 ratio = 50).<br>Administratiion of Nebivolol (initially by iv within 10 minutes of reperfusion and then orally) to rats with myocardial infarction (MI) reduces myocardial apoptosis, which is mediated by regulation of NO . Nebivolol, significantly, prevents left ventricular (LV) pressure changes, reduces total and regional apoptotic cardiomyocytes. Nebivolol treatment lowers mean blood pressure (MBP) in rats with MI slightly, but not significantly.

Catalog Number A000550
CAS Number 152520-56-4
Molecular Formula

C22H26ClF2NO4

Purity 95%
Target Adrenergic Receptor
Solubility Soluble in DMSO > 10 mM
Storage 3 years -20C powder

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