NCGC00244536

• CAT Number: I012063
• CAS Number: 2003260-55-5
• Molecular Formula: C17H16O4
• Molecular Weight: 284.31
• Purity: 98%
• Target: KDM4A inhibitor
• Solubility: DMSO
• Storage: Store at -20°C
• Analysis method: HPLC
• IUPAC Name: 3-(8-hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide
• InChI: InChI=1S/C25H22N2O2/c28-23-17-22(16-20-12-6-13-26-24(20)23)19-10-4-11-21(15-19)25(29)27-14-5-9-18-7-2-1-3-8-18/h1-4,6-8,10-13,15-17,28H,5,9,14H2,(H,27,29)
• InChIKey: NYKBXXGHEMXSBB-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)CCCNC(=O)C2=CC=CC(=C2)C3=CC(=C4C(=C3)C=CC=N4)O

NCGC00244536 （Cat No.: I012063）, is a potent inhibitor of the enzyme KDM4B, with an impressive IC50 value of 10 nanomolar (nM). KDM4B is involved in epigenetic regulation, particularly in processes related to gene expression. Beyond its action on KDM4B, NCGC00244536 also exhibits noteworthy potency in inhibiting the growth of various cancer cell lines, including breast cancer cell lines like MDA-MB2 and MCF-7, with IC50 values in the micromolar range. This suggests its potential as a valuable compound in cancer research, particularly for investigating epigenetic mechanisms and the development of targeted therapies for cancer treatment.