NBD-556

  • CAT Number: I003205
  • CAS Number: 333353-44-9
  • Molecular Formula: C17H24ClN3O2
  • Molecular Weight: 337.8
  • Purity: ≥95%
Inquiry Now

NBD-556 (Cat.No:I003205) is a small molecule compound that acts as a selective inhibitor of the Janus kinase 2 (JAK2) signaling pathway. It has shown promising potential for the treatment of various diseases, including myeloproliferative neoplasms and autoimmune disorders. NBD-556 selectively targets JAK2, a key enzyme involved in regulating immune responses and cell proliferation. Ongoing research aims to further explore its therapeutic applications.

Catalog Number I003205
CAS Number 333353-44-9
Molecular Formula

C17H24ClN3O2

Purity 95%
Target gp120/CD4
Solubility 10 mM in DMSO
Storage Store at -20°C
InChIKey ZKXLQCIOURANAD-UHFFFAOYSA-N
Reference

<p style=/line-height:25px/>
<br>[1]. Narumi, Tetsuo et al. CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist. Bioorganic & Medicinal Chemistry Letters (2010), 20(19), 5853-5858.

<br>[2]. Sch?n A, Madani N, Klein JC, Hubicki A, Ng D, Yang X, Smith AB 3rd, Sodroski J, Freire E.
Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120.
Biochemistry. 2006 Sep 12;45(36):10973-80.

<br>[3]. Singh IP, Chauthe SK.
Small molecule HIV entry inhibitors: Part II. Attachment and fusion inhibitors: 2004-2010.
Expert Opin Ther Pat. 2011 Mar;21(3):399-416.

<br>[4]. Zhao Q, Ma L, Jiang S, Lu H, Liu S, He Y, Strick N, Neamati N, Debnath AK.
Identification of N-phenyl-N/’-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4.
Virology. 2005 Sep 1;339(2):213-25.

</p>

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!