Nampt-IN-3

• CAT Number: I019119
• CAS Number: 2121591-52-2
• Molecular Formula: C₂₉H₂₅N₇O₂
• Molecular Weight: 503.55
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: N-(2-aminophenyl)-4-[[4-[4-(pyridin-3-ylmethylcarbamoyl)phenyl]triazol-1-yl]methyl]benzamide
• InChI: InChI=1S/C29H25N7O2/c30-25-5-1-2-6-26(25)33-29(38)24-9-7-20(8-10-24)18-36-19-27(34-35-36)22-11-13-23(14-12-22)28(37)32-17-21-4-3-15-31-16-21/h1-16,19H,17-18,30H2,(H,32,37)(H,33,38)
• InChIKey: LSGNVZAEAAZOEH-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CN3C=C(N=N3)C4=CC=C(C=C4)C(=O)NCC5=CN=CC=C5

Nampt-IN-3 (Cat No.:I019119) exhibits dual inhibition of nicotinamide phosphoribosyltransferase (NAMPT) and histone deacetylase (HDAC), with IC50 values of 31 nM and 55 nM, respectively. This compound is capable of inducing cell apoptosis and autophagy, ultimately leading to cell death. Nampt-IN-3 is a promising candidate for the treatment of various diseases, including cancer, due to its ability to target two critical pathways simultaneously.

Reference

[1]. Dong G, et al. Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors. J Med Chem. 2017 Oct 12;60(19):7965-7983.