For research use only. Not for therapeutic Use.
NAB2（Cat No.:I011109）is a small-molecule modulator identified for its ability to reverse α-synuclein-associated trafficking defects, making it a promising compound in Parkinson’s disease research. Originally discovered through phenotypic screening, NAB2 targets Nedd4, an E3 ubiquitin ligase, modulating its activity to restore cellular trafficking disrupted by α-synuclein toxicity. It does not inhibit α-synuclein aggregation directly but instead alleviates downstream cellular dysfunction. NAB2 is widely used to explore neuroprotective strategies and the role of ubiquitin signaling in neurodegeneration. It serves as a valuable tool in studying Parkinson’s disease pathogenesis and therapeutic development.
| CAS Number | 1504588-00-4 |
| Synonyms | N-[(2-chlorophenyl)methyl]-1-(2,5-dimethylphenyl)benzimidazole-5-carboxamide |
| Molecular Formula | C23H20ClN3O |
| Purity | ≥95% |
| IUPAC Name | N-[(2-chlorophenyl)methyl]-1-(2,5-dimethylphenyl)benzimidazole-5-carboxamide |
| InChI | InChI=1S/C23H20ClN3O/c1-15-7-8-16(2)22(11-15)27-14-26-20-12-17(9-10-21(20)27)23(28)25-13-18-5-3-4-6-19(18)24/h3-12,14H,13H2,1-2H3,(H,25,28) |
| InChIKey | CZSLEMCYYGEGKP-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1)C)N2C=NC3=C2C=CC(=C3)C(=O)NCC4=CC=CC=C4Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
