Mal-amido-PEG10-C2-​NHS ester

• CAT Number: I017852
• CAS Number: 1137109-22-8
• Molecular Formula: C₃₄H₅₅N₃O₁₇
• Molecular Weight: 777.81
• Purity: ≥95%
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C34H55N3O17/c38-29(5-8-36-30(39)1-2-31(36)40)35-7-10-45-12-14-47-16-18-49-20-22-51-24-26-53-28-27-52-25-23-50-21-19-48-17-15-46-13-11-44-9-6-34(43)54-37-32(41)3-4-33(37)42/h1-2H,3-28H2,(H,35,38)
• InChIKey: DUKFGPQZJAPKMG-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN2C(=O)C=CC2=O

Mal-amido-PEG10-C2-NHS ester (Cat No.: I017852) is a non-cleavable antibody-drug conjugate (ADC) linker that incorporates both a maleimide group and an N-hydroxysuccinimide (NHS) ester. NHS esters are widely utilized to label various biomolecules, including proteins, amine-modified oligonucleotides, and other amine-containing compounds with primary amines (-NH2). This linker provides a versatile platform for conjugating therapeutic agents to antibodies or other targeting molecules, enabling precise and stable delivery of drugs to specific cells or tissues in ADC development. Researchers can rely on it for efficient bioconjugation strategies in drug delivery and therapeutic applications.

Reference

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